The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity.
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Turning the RING domain protein MdmX into an active ubiquitin-protein ligaseThe SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein UnkemptSystematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networksMdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligaseProteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradationAn essential function of the extreme C-terminus of MDM2 can be provided by MDMXA comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome systemMutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stabilityAberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitinationRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisDeubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in transProtein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitorMolecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple MyelomaMDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activityRegulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damageMDM2 and MDMX: Alone and together in regulation of p53Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?Modes of p53 regulationMDM4 (MDMX) and its Transcript Variants.ATM activates p53 by regulating MDM2 oligomerization and E3 processivityMdm2 links genotoxic stress and metabolism to p53.PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated UbiquitinationMDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.Suppression of p53 activity by Siva1MDM2 oligomers: antagonizers of the guardian of the genome.Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.The p53 orchestra: Mdm2 and Mdmx set the toneOligomeric structure of the MALT1 tandem Ig-like domains.MDM2, MDMX and p53 in oncogenesis and cancer therapyRibosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesisPhosphatases in the cellular response to DNA damage.Nanosensing protein allostery using a bivalent mouse double minute two (MDM2) assayMechanism of p53 stabilization by ATM after DNA damage.Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.Deconstructing nucleotide binding activity of the Mdm2 RING domain.c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation.The MDM2 gene family.Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2.
P2860
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P2860
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The Mdm2 RING domain C-terminu ...... and ubiquitin ligase activity.
@ast
The Mdm2 RING domain C-terminu ...... and ubiquitin ligase activity.
@en
type
label
The Mdm2 RING domain C-terminu ...... and ubiquitin ligase activity.
@ast
The Mdm2 RING domain C-terminu ...... and ubiquitin ligase activity.
@en
prefLabel
The Mdm2 RING domain C-terminu ...... and ubiquitin ligase activity.
@ast
The Mdm2 RING domain C-terminu ...... and ubiquitin ligase activity.
@en
P2093
P2860
P356
P1433
P1476
The Mdm2 RING domain C-terminu ...... and ubiquitin ligase activity.
@en
P2093
Alex Kentsis
Carol Prives
Christina Priest
Katherine L B Borden
Masha V Poyurovsky
Nikola Pavletich
Zhen-Qiang Pan
P2860
P304
P356
10.1038/SJ.EMBOJ.7601465
P407
P577
2006-12-14T00:00:00Z