Therapeutic potential of AZD1480 for the treatment of human glioblastoma - Wikidata - wikimedia - TriplyDB

Therapeutic potential of AZD1480 for the treatment of human glioblastoma

Therapeutic potential of AZD1480 for the treatment of human glioblastoma

http://www.wikidata.org/entity/Q35613323

about

NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines Therapeutic modulators of STAT signalling for human diseases The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo.PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.Initial solid tumor testing (stage 1) of AZD1480, an inhibitor of Janus kinases 1 and 2 by the pediatric preclinical testing program.Dynamic analysis of GH receptor conformational changes by split luciferase complementation.α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial.Histone H3 phosphorylation in GBM: a new rational to guide the use of kinase inhibitors in anti-GBM therapy.JAK kinase inhibition abrogates STAT3 activation and head and neck squamous cell carcinoma tumor growth.Targeted Blockade of JAK/STAT3 Signaling Inhibits Ovarian Carcinoma Growth.Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas Tyrosine receptor kinase B is a drug target in astrocytomas.Loss of tumor suppressive microRNA-31 enhances TRADD/NF-κB signaling in glioblastoma Complexity of molecular alterations impacts pancreatic cancer prognosis.Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells.Modulating antiangiogenic resistance by inhibiting the signal transducer and activator of transcription 3 pathway in glioblastoma Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal.Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of glioma.NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma The Janus kinases inhibitor AZD1480 attenuates growth of small cell lung cancers in vitro and in vivo.Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis.STAT3/NF-κB-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer.JAK2 inhibition for the treatment of hematologic and solid malignancies.Interleukins in glioblastoma pathophysiology: implications for therapy.Inhibitors of JAK2 and JAK3: an update on the patent literature 2010 - 2012.Oncogene and non-oncogene addiction in inflammation-associated cancers.Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application.Selective JAK inhibitors.Antiangiogenic therapies for glioblastoma.d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway.Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma.Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration.DawnRank: discovering personalized driver genes in cancer.IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression.Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis.

P2860

Q26830388-20C77386-B047-43C6-9AFE-F97F04C0D130 Q27851932-D27DA7B6-D6DF-489D-9AEE-1800A4F8FA3A Q33684732-5EA7632F-A21F-4AF1-942B-737A1593EE30 Q34097238-265278EC-A553-4630-AACA-76D17B3BDD98 Q34297966-2E7C0DB8-9845-4D8A-9688-908625D2FB7C Q34361391-8DFD0E5E-7F9F-4521-8FC3-B7530BAB0115 Q34422493-1AD41B49-6457-4981-931E-4EBF72A41369 Q34523918-9020ADDF-281E-4236-87B2-D8D20E8429B0 Q34698607-9737E2A8-6ABE-4A8E-A407-7F4C60724AFA Q35214530-5E203927-E6A8-4472-850A-A2EFC7B18B7D Q35374753-9267BC1C-FFC6-40B7-BD1E-C721031D6501 Q35552014-9D1EC887-F02A-416E-B400-0B0F2D447FD0 Q36073551-22CDCDBD-9BE4-4788-9720-08E498BF5D40 Q36232178-146ED07F-18CE-4F00-A5C3-90BBE7C2C0E7 Q36563027-561DD076-036B-4B8B-B9FF-74C2E0B18E82 Q36737884-CFADA98D-43C8-4809-9514-FBEFF52FD84A Q36852167-93DE6253-76A5-448A-AFC5-3BFEB7E2F318 Q36862759-E1218D73-A35D-4B13-A0BD-197F9243214B Q36905859-531BD922-5187-458E-A704-D0B6E7698803 Q37029379-B2214E92-5B2F-43C2-86F5-86CD29EAA8FB Q37107598-63F62CE5-6DD2-48C0-9DF4-1EB5A1EC5BF7 Q37190394-D0A88A8B-6291-4932-8F88-39665D37BADA Q37297056-979BE5E2-D2EE-4662-BD90-09F264E51D11 Q37412314-2DCEDB4A-F37C-4A98-ABAB-8D59CCA38E63 Q37599312-5FCC5C71-1BFA-4B48-90FF-C71D4C25ADB9 Q37603419-843245FD-DA58-4CAF-9FFF-E39069DAB75F Q37668555-362A93DB-AA5E-46BE-92BE-83CFF99FF25B Q38001733-92A19CDD-8567-411F-995D-BC4E8ABDCF53 Q38051761-C425930E-85C5-4EE0-9732-D91C3B34083F Q38077992-6C1AC2D0-C0ED-483A-B6E1-4D084D640A17 Q38096415-A5DF8AC7-587B-49F4-97D4-D4B8F314F837 Q38164139-F6DA3373-2F28-477A-B1FB-959B47B268AE Q38261371-EEEDEB36-B199-4B38-9208-D8591A30559F Q38264310-6743F985-4070-45A5-92E5-BE99635893B4 Q38722856-7E3D9A61-2D29-4799-85D5-506885B6662C Q39778880-65C854C9-4539-4A02-92E0-EACCB1DC189A Q40768273-D294F900-CA53-4E67-8139-25EDE3F3E34F Q42849591-F8471EAB-4B15-4504-8397-279875BEA47F Q47758483-AEE1B92C-9220-4F01-BCA1-BAD1F06F1D29 Q47797453-9260EDF5-D778-4F53-8392-32C2091C4981

P2860

Therapeutic potential of AZD1480 for the treatment of human glioblastoma

http://www.wikidata.org/entity/Q35613323

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Therapeutic potential of AZD1480 for the treatment of human glioblastoma

@ast

Therapeutic potential of AZD1480 for the treatment of human glioblastoma

@en

type

label

Therapeutic potential of AZD1480 for the treatment of human glioblastoma

@ast

Therapeutic potential of AZD1480 for the treatment of human glioblastoma

@en

prefLabel

Therapeutic potential of AZD1480 for the treatment of human glioblastoma

@ast

Therapeutic potential of AZD1480 for the treatment of human glioblastoma

@en

P1433

Q35613323-6E604A02-B5B5-4857-B828-7E57DCCBDB91

P1476

Q35613323-A7CCE312-BEC4-42E3-86DD-C3B1A342A960

P2093

Q35613323-07B9AFD5-8E64-49A3-8A57-3D3D91FB3423

Q35613323-0804B52F-7B6D-4CC3-99CD-8B40BE030FAE

Q35613323-0E753626-E7D6-4C21-BB65-4CF83FFC1E39

Q35613323-15615F9E-F23D-4E0F-BB08-96E5689B3468

Q35613323-28E64458-EFE6-4BF9-A7A3-B19621952EAB

Q35613323-58C052BA-F034-4F3F-8E83-2553D88A605E

Q35613323-97531D3D-D0E6-4783-95E9-CAF3E97F9372

Q35613323-E3284BE2-C322-47CA-9BCA-E27804357732

P2860

Q35613323-02BB2EBA-345D-4D5E-8AC0-A14B59BAD035

Q35613323-14BC47D2-DC14-4F07-8308-08E78AF1C2F0

Q35613323-23EB022C-5193-4411-A225-ECC3755E975E

Q35613323-24386C5A-C6DE-4C4E-90AD-083D33440BE9

Q35613323-24E39B8F-2AF6-48A3-9A46-E2CE75E6130D

Q35613323-25BF1033-52E9-4F5C-A0A7-19F0DA4E9FA7

Q35613323-276FEE61-504D-4ECC-B955-81714B4F5854

Q35613323-2866A499-AF4E-4DE7-B0D8-F22FCDA56292

Q35613323-2BF11470-7277-4178-8066-7A929E1328B3

Q35613323-31D7FEF2-39F0-40D1-A215-324588EC7FC5

P304

Q35613323-CACAEA3C-2C48-497C-9963-91568B57CC6F

P31

Q35613323-87232290-5318-46D2-80CC-CD4EFE3BC312

P356

Q35613323-F34B76C1-B717-4291-A45C-4800D3B29A67

P433

Q35613323-65C7B153-1F1B-47C8-B019-9836ECDF0608

P478

Q35613323-F9B15E86-09D1-4E77-9EF0-810A81C89E2A

P50

Q35613323-50146DF1-8E96-410D-933A-E37710A11117

P577

Q35613323-DF02641D-72CF-4ADB-B240-D9A0D143B2C7

P698

Q35613323-F1AF35CD-4C54-43BF-8ED3-62736675EAB5

P932

Q35613323-3F7D808F-DADF-4E25-A891-F500A57960DF

P356

1535-7163.MCT-11-0480

P1433

Molecular Cancer Therapeutics

P1476

Therapeutic potential of AZD1480 for the treatment of human glioblastoma

@en

P2093

Catherine P Langford

http://www.w3.org/2001/XMLSchema#string

Dennis Huszar

http://www.w3.org/2001/XMLSchema#string

Etty N Benveniste

http://www.w3.org/2001/XMLSchema#string

G Yancey Gillespie

http://www.w3.org/2001/XMLSchema#string

Hao Yu

http://www.w3.org/2001/XMLSchema#string

Jing-Yuan Ma

http://www.w3.org/2001/XMLSchema#string

Susan E Nozell

http://www.w3.org/2001/XMLSchema#string

Ying Zheng

http://www.w3.org/2001/XMLSchema#string

P2860

Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.

Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Identification of human brain tumour initiating cells

Identification of a cancer stem cell in human brain tumors

SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor

P304

2384-2393

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1158/1535-7163.MCT-11-0480

http://www.w3.org/2001/XMLSchema#string

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

10

http://www.w3.org/2001/XMLSchema#string

P50

Braden C McFarland

P577

2011-10-25T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

22027691

http://www.w3.org/2001/XMLSchema#string

P932

3237864

http://www.w3.org/2001/XMLSchema#string