The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage.
about
The unfolded protein response in multiple sclerosisSystemic inflammation disrupts oligodendrocyte gap junctions and induces ER stress in a model of CNS manifestations of X-linked Charcot-Marie-Tooth disease.Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation.Interferon Gamma: Influence on Neural Stem Cell Function in Neurodegenerative and Neuroinflammatory DiseaseMultiple Sclerosis and Obesity: Possible Roles of AdipokinesTumor progression and the different faces of the PERK kinaseSOCS1 and SOCS3 in the control of CNS immunityImportance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination.Expression profiles of endoplasmic reticulum stress-related molecules in demyelinating lesions and multiple sclerosis.Transgenic models for cytokine-induced neurological disease.γδ T cell subsets play opposing roles in regulating experimental autoimmune encephalomyelitis.Interferon-γ inhibits central nervous system myelination through both STAT1-dependent and STAT1-independent pathwaysHyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis.Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice.Interferon-γ activates nuclear factor-κ B in oligodendrocytes through a process mediated by the unfolded protein response.PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.IFN-γ signaling to astrocytes protects from autoimmune mediated neurological disabilityUsing temporal genetic switches to synchronize the unfolded protein response in cell populations in vivo.Endoplasmic reticulum stress as a novel mechanism in amiodarone-induced destructive thyroiditisEndoplasmic reticulum stress in disorders of myelinating cells.Neurotrophin-3 targets the translational initiation machinery in oligodendrocytes.Oligodendrocyte progenitors reversibly exit the cell cycle and give rise to astrocytes in response to interferon-γ.Stimulation of adult oligodendrogenesis by myelin-specific T cellscFLIP is critical for oligodendrocyte protection from inflammationAttenuating the endoplasmic reticulum stress response improves functional recovery after spinal cord injury.Inhibition of Vascular Endothelial Growth Factor Receptor 2 Exacerbates Loss of Lower Motor Neurons and Axons during Experimental Autoimmune Encephalomyelitis.Phasic Treatment with Interferon Gamma Stimulates Release of Exosomes that Protect Against Spreading Depression.ER Chaperone BiP/GRP78 Is Required for Myelinating Cell Survival and Provides Protection during Experimental Autoimmune Encephalomyelitis.Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation.Harnessing the integrated stress response for the treatment of multiple sclerosis.The role of the unfolded protein response in myelinationOligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis.Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gammaRole of cytokine p40 family in multiple sclerosisA point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells.Overexpression of CHOP in Myelinating Cells Does Not Confer a Significant Phenotype under Normal or Metabolic Stress Conditions.Molecular mechanisms of the anti-inflammatory functions of interferonsPERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis.Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune encephalomyelitis.IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.
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P2860
The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The integrated stress response ...... gainst immune-mediated damage.
@ast
The integrated stress response ...... gainst immune-mediated damage.
@en
type
label
The integrated stress response ...... gainst immune-mediated damage.
@ast
The integrated stress response ...... gainst immune-mediated damage.
@en
prefLabel
The integrated stress response ...... gainst immune-mediated damage.
@ast
The integrated stress response ...... gainst immune-mediated damage.
@en
P2093
P2860
P50
P356
P1476
The integrated stress response ...... gainst immune-mediated damage.
@en
P2093
Samantha L Bailey
Stephen D Miller
P2860
P304
P356
10.1172/JCI29571
P407
P577
2007-02-01T00:00:00Z