Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability - Wikidata - wikimedia - TriplyDB

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

http://www.wikidata.org/entity/Q35621293

about

Links between metabolism and cancer Novel drugs that target the metabolic reprogramming in renal cell cancer Fundamentals of cancer metabolism Mitochondrial metabolic remodeling in response to genetic and environmental perturbations Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells Mitochondria in Cancer Energy Metabolism: Culprits or Bystanders?Exogenous Glutamine in Respiratory Diseases: Myth or Reality?Redox biology in pulmonary arterial hypertension (2013 Grover Conference Series)Hypoxia and metabolic adaptation of cancer cells Dysregulated metabolism contributes to oncogenesis Perspectives in the treatment of pancreatic adenocarcinoma Cancer metabolism: key players in metabolic reprogramming Metabolic reprogramming and metabolic dependency in T cells AMPK: opposing the metabolic changes in both tumour cells and inflammatory cells?A roadmap for interpreting (13)C metabolite labeling patterns from cells Autophagy: a targetable linchpin of cancer cell metabolism Genetically-defined metabolic reprogramming in cancer Glutamine and cancer: cell biology, physiology, and clinical opportunities How does the metabolism of tumour cells differ from that of normal cells Fueling immunity: insights into metabolism and lymphocyte function Targeting mitochondria metabolism for cancer therapy IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.Defects in mitochondrial metabolism and cancer Oncometabolites: Unconventional triggers of oncogenic signalling cascades On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment The mitochondrial side of epigenetics Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters Metabolic consequences of oncogenic IDH mutations 2-Hydoxyglutarate: D/Riving Pathology in gLiomaS A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels Mitochondrial health, the epigenome and healthspan Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells Use of nuclear magnetic resonance-based metabolomics to characterize the biochemical effects of naphthalene on various organs of tolerant mice Metformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis Critical Involvement of Environmental Carbon Dioxide Fixation to Drive Wax Ester Fermentation in Euglena Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism Metabolic reprogramming: a cancer hallmark even warburg did not anticipate Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

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Craig B Thompson

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Jesse M Platt

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Jessica E S Shay

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Joshua J Gruber

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M Celeste Simon

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Uma M Sachdeva

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P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria.

Understanding the Warburg effect: the metabolic requirements of cell proliferation

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

ATP-citrate lyase links cellular metabolism to histone acetylation

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