Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. - Wikidata - wikimedia - TriplyDB

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.

http://www.wikidata.org/entity/Q36946514

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Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides PTH receptor-1 signalling-mechanistic insights and therapeutic prospects Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors Administration frequency as well as dosage of PTH are associated with development of cortical porosity in ovariectomized rats.Chemical modification of class II G protein-coupled receptor ligands: frontiers in the development of peptide analogs as neuroendocrine pharmacological therapies Minireview: Spatial Programming of G Protein-Coupled Receptor Activity: Decoding Signaling in Health and Disease Backbone modification of a polypeptide drug alters duration of action in vivo.Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs Time-dependent changes in skeletal response to teriparatide: escalating vs. constant dose teriparatide (PTH 1-34) in osteoporotic women.Retromer terminates the generation of cAMP by internalized PTH receptors.International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling Endosomal generation of cAMP in GPCR signaling.Non-canonical signaling of the PTH receptor Fluorescent ligand-directed co-localization of the parathyroid hormone 1 receptor with the brush-border scaffold complex of the proximal tubule reveals hormone-dependent changes in ezrin immunoreactivity consistent with inactivation Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complex Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.Minireview: ubiquitination-regulated G protein-coupled receptor signaling and trafficking Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH PTH Signaling and Epigenetic Control of Bone Remodeling.Diphtheria Toxin- and GFP-Based Mouse Models of Acquired Hypoparathyroidism and Treatment With a Long-Acting Parathyroid Hormone Analog.Distinct G protein-coupled receptor recycling pathways allow spatial control of downstream G protein signaling.Six Weeks of Daily Abaloparatide Treatment Increased Vertebral and Femoral Bone Mineral Density, Microarchitecture and Strength in Ovariectomized Osteopenic Rats Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism.Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment.Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.GPCR Signaling and Trafficking: The Long and Short of It.Translating in vitro ligand bias into in vivo efficacy.Sustained signalling by PTH modulates IP3 accumulation and IP3 receptors through cyclic AMP junctions.Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys.Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist Parathyroid Hormone-Related Protein Promotes Rat Stem Leydig Cell Differentiation.Dual roles of parathyroid hormone related protein in TGF-β1 signaling and fibronectin up-regulation in mesangial cells.Kasabach-Merritt syndrome combined with hypercalcemia: A case report.Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad β Residue Distribution.Optimal dosing and delivery of parathyroid hormone and its analogues for osteoporosis and hypoparathyroidism - translating the pharmacology.Acute Parathyroid Hormone Injection Increases C-Terminal but Not Intact Fibroblast Growth Factor 23 Levels.G protein-coupled receptor modulation with pepducins: moving closer to the clinic

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P2860

Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.

http://www.wikidata.org/entity/Q36946514

description

2008 nî lūn-bûn

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2008年の論文

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Prolonged signaling at the par ...... pecific receptor conformation.

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Proceedings of the National Academy of Sciences of the United States of America

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Prolonged signaling at the par ...... pecific receptor conformation.

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Jean-Pierre Vilardaga

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John T Potts

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Makoto Okazaki

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Sebastien Ferrandon

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Thomas J Gardella

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P2860

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Molecular recognition of parathyroid hormone by its G protein-coupled receptor

Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism.

Continuous PTH and PTHrP infusion causes suppression of bone formation and discordant effects on 1,25(OH)2 vitamin D.

Beta-arrestin-biased ligands at seven-transmembrane receptors.

Parathyroid hormone for the treatment of osteoporosis: a systematic review.

Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations

Parathyroid hormone: a double-edged sword for bone metabolism.

Parathyroid hormone and parathyroid hormone-related peptide, and their receptors.

Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.

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16525-16530

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43

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105

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Mary L Bouxsein

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23409704

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18946036

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2571912

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