Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis
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Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cellsGlial cells as intrinsic components of non-cell-autonomous neurodegenerative diseaseActive and passive immunotherapy for neurodegenerative disordersProteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson diseaseTempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) formsEmerging mechanisms of molecular pathology in ALSMolecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosisParsing Disease-relevant Protein Modifications from Epiphenomena: Perspective on the Structural Basis of SOD1-Mediated ALS.Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS.Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric miceSex-dependent effects of chromogranin B P413L allelic variant as disease modifier in amyotrophic lateral sclerosisConformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases.Combined immunotherapy with "anti-insulin resistance" therapy as a novel therapeutic strategy against neurodegenerative diseases.A high-throughput screen to identify inhibitors of SOD1 transcription.Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal modelMarked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia.Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neuronsMisfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALSIdentification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1.Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathyDirect and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.Analysis of mutant SOD1 electrophoretic mobility by Blue Native gel electrophoresis; evidence for soluble multimeric assembliesLocalization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALSThe effect of amyotrophic lateral sclerosis-linked exogenous SOD1-G93A on electrophysiological properties and intracellular calcium in cultured rat astrocytes.Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical applicationAnti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis.Motor neuron-immune interactions: the vicious circle of ALS.Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosisImmunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission?TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashionMutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosisGlutamate excitotoxicity and therapeutic targets for amyotrophic lateral sclerosis.Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1.Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.FTD and ALS: a tale of two diseasesSOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy.
P2860
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P2860
Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Therapeutic effects of immuniz ...... amyotrophic lateral sclerosis
@ast
Therapeutic effects of immuniz ...... amyotrophic lateral sclerosis
@en
type
label
Therapeutic effects of immuniz ...... amyotrophic lateral sclerosis
@ast
Therapeutic effects of immuniz ...... amyotrophic lateral sclerosis
@en
prefLabel
Therapeutic effects of immuniz ...... amyotrophic lateral sclerosis
@ast
Therapeutic effects of immuniz ...... amyotrophic lateral sclerosis
@en
P2093
P2860
P356
P1476
Therapeutic effects of immuniz ...... amyotrophic lateral sclerosis
@en
P2093
Jean-Pierre Julien
Makoto Urushitani
Samer Abou Ezzi
P2860
P304
P356
10.1073/PNAS.0606201104
P407
P577
2007-02-02T00:00:00Z