Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.
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Emerging preclinical pharmacological targets for Parkinson's diseaseMechanism of Anti-α-Synuclein ImmunotherapyImmunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein AggregationDisease-modifying therapeutic directions for Lewy-Body dementiasSelf-propagation of pathogenic protein aggregates in neurodegenerative diseasesVaccination strategies for Parkinson disease: induction of a swift attack or raising tolerance?Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic targetNon-pharmacological cognitive intervention for aging and dementia: Current perspectivesPassive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy modelsMore than a Rumor Spreads in Parkinson's DiseaseAlpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body DisordersSpreading of pathology in neurodegenerative diseases: a focus on human studiesAntidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophyHeat shock proteins in neurodegenerative disorders and agingNext-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.The Cleavage Effect of Mesenchymal Stem Cell and Its Derived Matrix Metalloproteinase-2 on Extracellular α-Synuclein Aggregates in Parkinsonian ModelsAutoimmune antibody decline in Parkinson's disease and Multiple System Atrophy; a step towards immunotherapeutic strategies.Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microgliaNanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway.The role of Galectin-3 in α-synuclein-induced microglial activation.Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutationNaturally occurring alpha-synuclein autoantibodies in Parkinson's disease: sources of (error) variance in biomarker assays.Novel therapeutic approaches in multiple system atrophyAltered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease.Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease.A generic method for design of oligomer-specific antibodies.Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophyGlucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein.The Interplay between Alpha-Synuclein Clearance and SpreadingAutophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain.Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia.Targeting protein aggregation for the treatment of degenerative diseases
P2860
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P2860
Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Antibody-aided clearance of ex ...... o-cell aggregate transmission.
@en
Antibody-aided clearance of ex ...... o-cell aggregate transmission.
@nl
type
label
Antibody-aided clearance of ex ...... o-cell aggregate transmission.
@en
Antibody-aided clearance of ex ...... o-cell aggregate transmission.
@nl
prefLabel
Antibody-aided clearance of ex ...... o-cell aggregate transmission.
@en
Antibody-aided clearance of ex ...... o-cell aggregate transmission.
@nl
P2093
P2860
P1476
Antibody-aided clearance of ex ...... o-cell aggregate transmission.
@en
P2093
Dong-Hwan Ho
Eun-Bi Park
Eun-Jin Bae
He-Jin Lee
Na-Young Yang
Paula Desplats
Seung-Jae Lee
P2860
P304
13454-13469
P356
10.1523/JNEUROSCI.1292-12.2012
P407
P577
2012-09-01T00:00:00Z