Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission. - Wikidata - wikimedia - TriplyDB

Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.

Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.

http://www.wikidata.org/entity/Q37117527

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Emerging preclinical pharmacological targets for Parkinson's disease Mechanism of Anti-α-Synuclein Immunotherapy Immunotherapy in Parkinson's Disease: Micromanaging Alpha-Synuclein Aggregation Disease-modifying therapeutic directions for Lewy-Body dementias Self-propagation of pathogenic protein aggregates in neurodegenerative diseases Vaccination strategies for Parkinson disease: induction of a swift attack or raising tolerance?Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target Non-pharmacological cognitive intervention for aging and dementia: Current perspectives Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models More than a Rumor Spreads in Parkinson's Disease Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders Spreading of pathology in neurodegenerative diseases: a focus on human studies Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy Heat shock proteins in neurodegenerative disorders and aging Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials.ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.The Cleavage Effect of Mesenchymal Stem Cell and Its Derived Matrix Metalloproteinase-2 on Extracellular α-Synuclein Aggregates in Parkinsonian Models Autoimmune antibody decline in Parkinson's disease and Multiple System Atrophy; a step towards immunotherapeutic strategies.Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway.The role of Galectin-3 in α-synuclein-induced microglial activation.Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation Naturally occurring alpha-synuclein autoantibodies in Parkinson's disease: sources of (error) variance in biomarker assays.Novel therapeutic approaches in multiple system atrophy Altered serum IgG levels to α-synuclein in dementia with Lewy bodies and Alzheimer's disease.Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice.Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease.A generic method for design of oligomer-specific antibodies.Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein.The Interplay between Alpha-Synuclein Clearance and Spreading Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain.Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake.A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders.Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia.Targeting protein aggregation for the treatment of degenerative diseases

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Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.

http://www.wikidata.org/entity/Q37117527

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bilimsel makale

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scientific article published on September 2012

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Antibody-aided clearance of ex ...... o-cell aggregate transmission.

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Antibody-aided clearance of ex ...... o-cell aggregate transmission.

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Antibody-aided clearance of ex ...... o-cell aggregate transmission.

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JNEUROSCI.1292-12.2012

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Journal of Neuroscience

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Antibody-aided clearance of ex ...... o-cell aggregate transmission.

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Dong-Hwan Ho

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Eun-Bi Park

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Eun-Jin Bae

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He-Jin Lee

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Na-Young Yang

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Paula Desplats

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Seung-Jae Lee

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P2860

alpha-Synuclein and neuronal cell death

Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.

Transmission and spreading of tauopathy in transgenic mouse brain

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

Recognition of immunoglobulins by Fcgamma receptors

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13454-13469

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scholarly article

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10.1523/JNEUROSCI.1292-12.2012

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39

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Eliezer Masliah

Edward Rockenstein

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2012-09-01T00:00:00Z

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23015436

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3752153

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