Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
about
Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosisComplexins: small but capableCa²⁺-regulated secretory granule exocytosis in pancreatic and parotid acinar cellsDistinct initial SNARE configurations underlying the diversity of exocytosisLateral diffusion of proteins on supported lipid bilayers: additive friction of synaptotagmin 7 C2A-C2B tandem domains.Synaptic vesicles position complexin to block spontaneous fusionInjured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.Ring-like oligomers of Synaptotagmins and related C2 domain proteinsAn extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly.SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium.Synaptotagmin-1 binds to PIP(2)-containing membrane but not to SNAREs at physiological ionic strengthThe juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding.Synaptic transmission between end bulbs of Held and bushy cells in the cochlear nucleus of mice with a mutation in Otoferlin.Studying calcium-triggered vesicle fusion in a single vesicle-vesicle content and lipid-mixing system.Calcium sensitive ring-like oligomers formed by synaptotagminPhosphatidylinositol 4,5-bisphosphate: targeted production and signalingPhosphatidylserine in the brain: metabolism and function.A sequential vesicle pool model with a single release sensor and a Ca(2+)-dependent priming catalyst effectively explains Ca(2+)-dependent properties of neurosecretion.Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter releaseThe synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening.Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.Calcium binding promotes conformational flexibility of the neuronal Ca(2+) sensor synaptotagmin.Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion.Exocytotic fusion pores are composed of both lipids and proteins.Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent mannerComplexin-1 enhances the on-rate of vesicle docking via simultaneous SNARE and membrane interactions.Exocytosis and synaptic vesicle function.The role of phosphoinositides in synapse function.PI(4,5)P₂-binding effector proteins for vesicle exocytosis.Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance rulerSynaptotagmin 1 and Ca2+ drive trans SNARE zippering.Circular oligomerization is an intrinsic property of synaptotagmin.Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.SNARE and regulatory proteins induce local membrane protrusions to prime docked vesicles for fast calcium-triggered fusion.Reconstitution of calcium-mediated exocytosis of dense-core vesicles.A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13.Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering.
P2860
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P2860
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
@ast
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
@en
type
label
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
@ast
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
@en
prefLabel
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
@ast
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
@en
P2093
P2860
P356
P1476
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion.
@en
P2093
Edwin R Chapman
Huisheng Liu
P2860
P304
P356
10.1083/JCB.201104079
P407
P577
2011-12-19T00:00:00Z