Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications.
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An allosteric enhancer of M₄ muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaineCharacterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligandSystematic Review of Pharmacological Properties of the Oligodendrocyte LineageKCNQ potassium channels in sensory system and neural circuitsHealth Span-Extending Activity of Human Amniotic Membrane- and Adipose Tissue-Derived Stem Cells in F344 Rats.Activities of nicotinic acetylcholine receptors modulate neurotransmission and synaptic architectureDiscovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatinsMuscarinic agonists for the treatment of cognition in schizophreniaApplication of Neurochemical Markers for Assessing Health Effects after Developmental Methylmercury and PCB CoexposureLethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout miceModulation of prepulse inhibition through both M(1) and M (4) muscarinic receptors in miceKnockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus.M4 muscarinic receptor knockout mice display abnormal social behavior and decreased prepulse inhibition.Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability.A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairmentLack of association of a spontaneous mutation of the Chrm2 gene with behavioral and physiologic phenotypic differences in inbred miceM1 muscarinic receptor for the development of auditory cortical function.A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learningIncreased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.Muscarinic receptor-mediated bronchoconstriction is coupled to caveolae in murine airwaysDirected molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs.Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia.Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses.Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity.Mechanisms of M3 muscarinic receptor regulation by wash-resistant xanomeline bindingIntestinal epithelial stem/progenitor cells are controlled by mucosal afferent nervesMuscarinic receptor subtypes as potential targets to modulate oligodendrocyte progenitor survival, proliferation, and differentiation.Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticusInhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampusStimulation of muscarinic receptors mimics experience-dependent plasticity in the honey bee brain.Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex.Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function.Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice.M1 muscarinic receptor activation mediates cell death in M1-HEK293 cellsThe C. elegans VIG-1 and FRM-1 modulate carbachol-stimulated ERK1/2 activation in chinese hamster ovary cells expressing the muscarinic acetylcholine receptor GAR-3.Identification of the muscarinic acetylcholine receptor subtype mediating cholinergic vasodilation in murine retinal arteriolesPresynaptic muscarinic M(2) receptors modulate glutamatergic transmission in the bed nucleus of the stria terminalis.The selective M1 muscarinic cholinergic agonist CDD-0102A enhances working memory and cognitive flexibility.
P2860
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P2860
Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Muscarinic acetylcholine recep ...... pes and clinical implications.
@ast
Muscarinic acetylcholine recep ...... pes and clinical implications.
@en
type
label
Muscarinic acetylcholine recep ...... pes and clinical implications.
@ast
Muscarinic acetylcholine recep ...... pes and clinical implications.
@en
prefLabel
Muscarinic acetylcholine recep ...... pes and clinical implications.
@ast
Muscarinic acetylcholine recep ...... pes and clinical implications.
@en
P1476
Muscarinic acetylcholine recep ...... pes and clinical implications.
@en
P2093
Jürgen Wess
P304
P356
10.1146/ANNUREV.PHARMTOX.44.101802.121622
P577
2004-01-01T00:00:00Z