A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning
about
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learningRapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptorsDiscovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probeM1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis productDiscovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairmentThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsSelective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation.Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathyData regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stressSynthesis and SAR of N-(4-(4-alklylpiperazin-1-yl)phenyl)benzamides as muscarinic acetylcholine receptor subtype 1 (M1) anatgonists.All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium.The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent mannerModes and models of forebrain cholinergic neuromodulation of cognition.Identification of muscarinic receptor subtypes involved in catecholamine secretion in adrenal medullary chromaffin cells by genetic deletion.An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult ratsMuscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures.M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease.M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice.M2 muscarinic acetylcholine receptors regulate long-term potentiation at hippocampal CA3 pyramidal cell synapses in an input-specific fashion.Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms.An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.Synaptic muscarinic response types in hippocampal CA1 interneurons depend on different levels of presynaptic activity and different muscarinic receptor subtypes.Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.Effects of M1 and M4 activation on excitatory synaptic transmission in CA1.Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe.Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012.Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists.Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012.Anticholinergic drugs rescue synaptic plasticity in DYT1 dystonia: role of M1 muscarinic receptors.Muscarinic M1 receptor and cannabinoid CB1 receptor do not modulate paraoxon-induced seizures.Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord.Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine.Muscarinic receptor signaling contributes to atypical antipsychotic drug reversal of the phencyclidine-induced deficit in novel object recognition in rats.
P2860
Q24657785-7E4B4406-A379-4D8D-AD93-2BB63C6FDABFQ27308009-1DADB087-914A-4396-A6E0-45101D4BC48DQ28237300-0C1E31A1-6E6E-45EB-8D38-13BEF6176E6EQ28270501-56131D0C-204B-4C85-A4A9-7470C8E22ACEQ28300950-00123FA7-5411-4FC6-BCC2-DB94D47CA010Q30472643-B72B5591-BF32-4451-9515-DD8E3007C749Q30474039-CB030FA0-9820-441A-896A-086DD321525EQ30475205-F6F4AED0-686C-46E6-B5D4-AE4B64A280D0Q30486707-4CFAE3BB-54FD-4FF8-B655-C9C8E9780594Q30489795-1732E8CD-0C07-40C1-8579-64A7EA553F5AQ30830269-C28B4DA4-17D6-451D-A657-49A0A0085054Q30836715-C9350056-12D2-4A9D-A945-0D72EFD89939Q31044070-92A1C346-00E2-4027-A0D1-35E4F5DD5F26Q33536927-55F1AE5C-B435-4204-97C8-39A85F9A68CBQ33895150-DC36A9DE-D02B-4FFE-BEDC-F6AC77C10D50Q33927277-4EE647F0-BC7A-42DF-BC89-D9043B66DEC8Q34355481-075C44AD-54D8-4DD2-A33F-DBD6F67103C3Q34447665-11568346-B432-48DA-A924-3D15242BC8BAQ35043462-3A844798-0EE4-482E-936E-6146447ADFDFQ35118152-BAE86BF5-44E4-499A-B009-6F0C64E3F4C1Q35353753-E481D110-E100-4249-8F78-26D526CEFC3DQ35776844-F025A286-A1D8-46C5-87CD-F1F2E3A46043Q36064546-529CD72E-DC0C-4472-8459-051FAC13B49BQ36211330-11E6C903-FA97-46B9-8327-DED2A75BC0D3Q36573164-52ACDD90-1F37-4613-9C93-E861171DB4D9Q36884749-F4B8B160-2F87-4BE1-8E92-6C648FB731E6Q37197371-BA2458A3-29AE-4235-BEE1-EBF79CF7176DQ38665289-CDE2A0FF-E7B9-415A-8951-C3623F9D5DF4Q39222571-13006A5D-FFA2-4D1A-A229-E2E0FF566D42Q41540365-55D565D4-5924-4B23-AED0-AD5FA0E0A033Q41828999-9BD90D43-F244-45E1-95C7-1D445215EEA0Q41855867-85B11EF9-3F33-44CF-9289-A153E8661D02Q41881891-32829829-380A-4491-8816-74558EDFEFA2Q42323359-68292012-31CB-4ADD-A28B-7C10FDAF084EQ42971243-C6070045-4435-41A0-B152-33270EA298FCQ43132098-8974C265-BBB9-4BD6-966D-7888A126B6C7Q44465467-0DB33C97-65A4-4D66-B8E1-BB19E994B87CQ46379917-D451580D-A14E-44AE-997D-4254693A3596Q47814036-F5DADD0E-5F92-49EF-942E-238E9403D7ADQ47925112-BED3D926-7F0A-48CD-A0EE-5C6D796BFE28
P2860
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A novel selective muscarinic a ...... hippocampus-dependent learning
@ast
A novel selective muscarinic a ...... hippocampus-dependent learning
@en
type
label
A novel selective muscarinic a ...... hippocampus-dependent learning
@ast
A novel selective muscarinic a ...... hippocampus-dependent learning
@en
prefLabel
A novel selective muscarinic a ...... hippocampus-dependent learning
@ast
A novel selective muscarinic a ...... hippocampus-dependent learning
@en
P2093
P2860
P50
P356
P1476
A novel selective muscarinic a ...... hippocampus-dependent learning
@en
P2093
Alexander S Kane
Carrie K Jones
Charles D Weaver
Douglas J Sheffler
Fang Zheng
L Michelle Lewis
Mathew M Mock
Nellie E Byun
Richard Williams
Satyawan Jadhav
P2860
P304
P356
10.1124/MOL.109.056531
P577
2009-04-30T00:00:00Z