Regulation of autophagy by neuropathological protein TDP-43.
about
Ubiquilin-2 (UBQLN2) binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells: characterization of inhibition by nucleic acids and 4-aminoquinolinesRecent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)The Function of Autophagy in Neurodegenerative DiseasesConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisTherapeutic and diagnostic challenges for frontotemporal dementiaRNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress responseTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Frontotemporal dementia: a bridge between dementia and neuromuscular diseaseMechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cellsLoss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell deathOverexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice.Astrocytic TDP-43 pathology in Alexander diseaseProtein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia ContinuumProteasome dysfunction induces muscle growth defects and protein aggregation.Targeting RNA binding proteins involved in neurodegeneration.A systems biology investigation of neurodegenerative dementia reveals a pivotal role of autophagy.Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis.Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life spanActivation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the MutationCharacterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function.Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice.Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43CD47 deficiency confers cell and tissue radioprotection by activation of autophagy.Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.RNA-mediated toxicity in neurodegenerative diseaseTherapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS.Tdp-43 cryptic exons are highly variable between cell types.Aggrephagy: selective disposal of protein aggregates by macroautophagy.Iron and Neurodegeneration: Is Ferritinophagy the Link?TDP-43 expression influences amyloidβ plaque deposition and tau aggregation.Stress granules at the intersection of autophagy and ALS.TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathwaysPeptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.Emerging connections between RNA and autophagy.Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral SclerosisAutophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72.TDP-43 in the spectrum of MND-FTLD pathologies.Rapamycin alleviates pathogenesis of a new Drosophila model of ALS-TDP.TDP-43/HDAC6 axis promoted tumor progression and regulated nutrient deprivation-induced autophagy in glioblastoma.
P2860
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P2860
Regulation of autophagy by neuropathological protein TDP-43.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Regulation of autophagy by neuropathological protein TDP-43.
@ast
Regulation of autophagy by neuropathological protein TDP-43.
@en
type
label
Regulation of autophagy by neuropathological protein TDP-43.
@ast
Regulation of autophagy by neuropathological protein TDP-43.
@en
prefLabel
Regulation of autophagy by neuropathological protein TDP-43.
@ast
Regulation of autophagy by neuropathological protein TDP-43.
@en
P2093
P2860
P356
P1476
Regulation of autophagy by neuropathological protein TDP-43.
@en
P2093
C-K James Shen
Chi-Chen Huang
Jayarama Krishnan Bose
P2860
P304
44441-44448
P356
10.1074/JBC.M111.237115
P407
P577
2011-11-03T00:00:00Z