Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43 - Wikidata - wikimedia - TriplyDB

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

http://www.wikidata.org/entity/Q36236376

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mTOR is a key modulator of ageing and age-related disease Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function Toward precision medicine in amyotrophic lateral sclerosis Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration The search for antiaging interventions: from elixirs to fasting regimens Autophagy and neurodegeneration Gain of BDNF Function in Engrafted Neural Stem Cells Promotes the Therapeutic Potential for Alzheimer's Disease.Autophagy: an adaptive physiological countermeasure to cellular senescence and ischaemia/reperfusion-associated cardiac arrhythmias TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.A Single Postnatal Dose of Dexamethasone Enhances Memory of Rat Pups Later in Life.Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death Spermidine protects against α-synuclein neurotoxicity.mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies.Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Continuum Longevity pathways and memory aging RNA metabolism in neurodegenerative disease.Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage.Late-onset dementia: a mosaic of prototypical pathologies modifiable by diet and lifestyle.Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.Cardioprotection and lifespan extension by the natural polyamine spermidine.Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis Spermidine induces autophagy by inhibiting the acetyltransferase EP300.Suppressed autophagy flux in skeletal muscle of an amyotrophic lateral sclerosis mouse model during disease progression.Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis.Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy.Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy.Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers.PABPN1 suppresses TDP-43 toxicity in ALS disease models.Spermidine on neurodegenerative diseases.Compartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesis Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

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Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

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Autophagy activators rescue an ...... the TAR DNA-binding protein 43

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Bo-Shen Guo

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Che-Kun James Shen

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Cheng-Chun Wu

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Chun-Hung Yang

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I-Fang Wang

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Kuen-Jer Tsai

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Yu-Chih Liu

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P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Fighting neurodegeneration with rapamycin: mechanistic insights

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

The role of TOR in autophagy regulation from yeast to plants and mammals

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