Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. - Wikidata - wikimedia - TriplyDB

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.

http://www.wikidata.org/entity/Q35642820

about

Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia Hematopoietic stem cell gene therapy:assessing the relevance of preclinical models Retroviral integrations in gene therapy trials Aging of the microenvironment influences clonality in hematopoiesis.Long-term vector integration site analysis following retroviral mediated gene transfer to hematopoietic stem cells for the treatment of HIV infection.Transcription factor binding sites are genetic determinants of retroviral integration in the human genome.Concise review: lessons learned from clinical trials of gene therapy in monogenic immunodeficiency diseases.Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance.Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis.Ectopic expression of HOXC6 blocks myeloid differentiation and predisposes to malignant transformation.Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation.Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy.Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector The role of HIV integration in viral persistence: no more whistling past the proviral graveyard.Transgenic sheep generated by lentiviral vectors: safety and integration analysis of surrogates and their offspring.Unaltered repopulation properties of mouse hematopoietic stem cells transduced with lentiviral vectors.Does retroviral insertional mutagenesis play a role in the generation of induced pluripotent stem cells?Insertional mutagenesis and clonal dominance: biological and statistical considerations.Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples.The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy Automated analysis of viral integration sites in gene therapy research using the SeqMap web resource Identification of Hematopoietic Stem Cell Engraftment Genes in Gene Therapy Studies.Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation.Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.Genotoxicity of retroviral hematopoietic stem cell gene therapy.Ex vivo gene transfer and correction for cell-based therapies.Lentiviral hematopoietic stem cell gene therapy in inherited metabolic disorders.Integration site and clonal expansion in human chronic retroviral infection and gene therapy.A Lentiviral Fluorescent Genetic Barcoding System for Flow Cytometry-Based Multiplex Tracking.Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions.Transgene optimization significantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells.

P2860

Q24617126-6C67D234-7A1C-4D47-9792-3C44A6A5DB61 Q24618997-43471D90-5377-48EB-8869-5FFF03928BCD Q26859147-A008A5EA-746B-4C35-9C87-37738CA54E3D Q26991660-20557E4F-3532-43AD-BF4D-AD52B82B6718 Q31081388-DD391EFC-AF9A-483D-B502-B9E00DADDB90 Q33400359-5E4BA5B7-6CA9-41E5-8988-860EC80D08DD Q33411772-A091767B-B9E3-4A83-9522-4428620B865E Q33552027-5FC8878A-E52E-4BD8-A35C-E07A604F9652 Q33686199-69A0FBC3-557D-482B-B9D2-F426813A5DE4 Q33712953-46F761BF-F409-48B1-851A-B7C0C2387CEE Q33713156-6F0F404C-3780-465B-B333-4A4387070A96 Q33713961-9896F19C-0BB9-4515-9C60-2B5D5696131E Q33772702-529762D5-1425-4E51-BD61-5AFF2E23666B Q34209811-59C37919-24D1-4048-BE81-3532D8EDB3F0 Q34484917-E4AD1446-9489-4C10-8969-17F82397E0F5 Q34694796-18E3ACBB-EBC8-45AE-B860-85343682CA06 Q35568549-446E0538-AF57-47B8-AB4A-0571F5A8D936 Q36088939-68CFA3FF-E260-4A0F-976F-BABD5FC8F646 Q36141856-AD10A620-0991-4257-9BE7-44E4BA98EDFD Q36470463-C28C1274-15B8-430B-BFAA-24B57E31DAA8 Q36499435-C597835A-EDF4-4977-8B72-372E2810DB87 Q36515181-3F2C9A1B-B462-4AC5-8641-2DF155B71AB1 Q36710283-4CE2EBF7-43F6-4885-89F1-680D6CE1EF83 Q36941057-C3BDEC75-157C-43CD-8603-117AA6946379 Q36947161-6DB5791C-D389-4A5D-858B-4EB15D4BE190 Q36986958-78CB0175-7BF0-4796-B159-2E4078125ABC Q37066318-C8F9405D-1A31-4A5E-922A-49736BA14FDD Q37143395-25C1CEB5-5264-4B86-B459-5EBF5AB3E76F Q37398021-86302577-EA97-4332-A20A-6F7E6D56C796 Q37419345-A79AEA3E-D630-46DE-A5C2-608E945FC63C Q37480480-4689BEB0-174B-4883-9029-58B4FE22FCB5 Q37480567-63FDFC1F-6837-4EA3-80ED-746207A3B4A0 Q37849774-C9D56C26-78B3-496E-81C6-483523C1A6E8 Q37858878-03776136-8462-4897-8723-F42CCE801775 Q38245751-4CE1E235-5D79-4E3D-9C08-A13E4A8E2D4A Q38264568-B8F42605-98BC-4437-8F30-E75B9E5FA12F Q38933106-8726A974-6A01-48A3-A6B6-51707622CCDA Q39232300-61CEFD4F-3EAD-42A1-A50B-800D9F1D06DA Q39917097-C9FF97C5-FED4-4CF8-9CDC-EE1771B72455 Q39941137-CE3E4DD5-7242-47EB-BA47-BDFE41A08643

P2860

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.

http://www.wikidata.org/entity/Q35642820

description

2006 nî lūn-bûn

@nan

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

2006年论文

@zh

2006年论文

@zh-cn

name

Retroviral vector insertion si ...... ones mark "stemness" pathways.

@ast

Retroviral vector insertion si ...... ones mark "stemness" pathways.

@en

type

label

Retroviral vector insertion si ...... ones mark "stemness" pathways.

@ast

Retroviral vector insertion si ...... ones mark "stemness" pathways.

@en

prefLabel

Retroviral vector insertion si ...... ones mark "stemness" pathways.

@ast

Retroviral vector insertion si ...... ones mark "stemness" pathways.

@en

P1433

Q35642820-68C6FFEA-F74E-4184-BD5F-A1501289E65A

P1476

Q35642820-880848A1-7828-44F6-B70A-FC7DCE7872E7

P2093

Q35642820-05716BB0-252D-4506-9CC2-DF90A95CE007

Q35642820-05A4658D-2C94-4F79-BA60-EE4D226EF127

Q35642820-15A7869D-817D-42F7-B0D3-3457333EA932

Q35642820-16BC8125-F3AF-47D4-B7B7-80B7938FEB2C

Q35642820-23312002-0A2A-4428-A65D-F2085846AB86

Q35642820-52D5E715-2849-426A-9EF9-71CF14694122

Q35642820-61DB9038-60D5-4819-AF38-BEF718D3072F

Q35642820-74003473-2405-4477-A5CD-1E632E69977F

Q35642820-95A591AD-600D-4314-89E4-F23291615498

Q35642820-CDCC7D1F-F675-4431-89C7-7D305E3B64E2

P2860

Q35642820-053DB2BF-8300-4D49-A10F-C76AD94A1C3A

Q35642820-05AE6B2E-54F5-449C-98FB-A1D9C49255BC

Q35642820-0BC072A4-23F2-45F4-9304-9410334CB926

Q35642820-16981814-B624-47CB-96BC-B07997BAA240

Q35642820-2023541C-3D3E-483F-9575-20667AAAB427

Q35642820-21C875ED-A925-43A0-AD5D-7B8610F4EAC1

Q35642820-240A27ED-CA0E-427E-A0E7-0534D8AE2B78

Q35642820-253D8A55-ED28-4A26-B1B7-E52E0D0A6B8E

Q35642820-2C7AE25A-8790-4C21-A24A-3524741B10B6

Q35642820-2CF693FE-EB68-4CB3-B506-C4D515F140C7

P304

Q35642820-0CC650B2-18E1-4831-93CC-780100B168B0

P31

Q35642820-E75C0C3F-B4A0-4741-87E8-E8F5D5D28FF8

P356

Q35642820-D482044F-374B-4790-9F39-D739D46A7C3D

P407

Q35642820-90FAD10A-A6C4-4101-8EF6-7F7D8B41D02C

P433

Q35642820-E103A1B0-1A15-4C29-A118-351B4B378FBD

P478

Q35642820-0B7DE102-0B95-4C02-8783-2640CC887C52

P50

Q35642820-0A73B2B8-FE4E-475F-B33A-935254C2CE2B

Q35642820-2BAF5DE8-E859-4496-889A-DC2E69F2D1E8

Q35642820-D97BCA17-BBDE-4749-AE28-47BC325B6238

Q35642820-EBCB12BA-D2F9-4A8D-B2B5-84F7D476BBD5

P577

Q35642820-578867F1-0715-4101-9C65-B4C7F77B226A

P5875

Q35642820-999F78A6-A6DA-43AF-8F88-DC867C31BECE

P698

Q35642820-86F56415-F66D-4A70-AE29-942DAC5B0125

P932

Q35642820-835CE139-50D6-4FE2-92E5-2BEE5586860E

P356

BLOOD-2006-08-044156

P1433

P1476

Retroviral vector insertion si ...... ones mark "stemness" pathways.

@en

P2093

Christopher Baum

http://www.w3.org/2001/XMLSchema#string

Dick de Ridder

http://www.w3.org/2001/XMLSchema#string

Frank J T Staal

http://www.w3.org/2001/XMLSchema#string

Gerard Wagemaker

http://www.w3.org/2001/XMLSchema#string

Gottfried von Keudell

http://www.w3.org/2001/XMLSchema#string

Hartmut Geiger

http://www.w3.org/2001/XMLSchema#string

Kalpana Jekumar Nattamai

http://www.w3.org/2001/XMLSchema#string

Karin Pike-Overzet

http://www.w3.org/2001/XMLSchema#string

Kerstin Cornils

http://www.w3.org/2001/XMLSchema#string

Olga S Kustikova

http://www.w3.org/2001/XMLSchema#string

P2860

Initial sequencing and comparative analysis of the mouse genome

Molecular signatures of proliferation and quiescence in hematopoietic stem cells

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

EVI1 and hematopoietic disorders: history and perspectives

Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells

Transcription start regions in the human genome are favored targets for MLV integration

HIV-1 integration in the human genome favors active genes and local hotspots

P304

1897-1907

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1182/BLOOD-2006-08-044156

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

109

http://www.w3.org/2001/XMLSchema#string

P50

Margaret A Goodell

Martijn Brugman

P577

2006-11-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6679145

http://www.w3.org/2001/XMLSchema#string

P698

17119121

http://www.w3.org/2001/XMLSchema#string

P932

1801061

http://www.w3.org/2001/XMLSchema#string