Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents
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Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsCDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiationIn Situ Observation of Thiol Michael Addition to a Reversible Covalent Drug in a Crystalline Sponge.Low-Dose Dose-Response for In Vitro Nrf2-ARE Activation in Human HepG2 CellsNrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and HumansPharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.(±)-(4bS,8aR,10aS)-10a-Ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octa-hydro-phenanthrene-2,6-dicarbonitrile.Renoprotection and the Bardoxolone Methyl Story - Is This the Right Way Forward? A Novel View of Renoprotection in CKD Trials: A New Classification Scheme for Renoprotective Agents.NAD(P)H: quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives.Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method.Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.Opening or closing the lock? When reactivity is the key to biological activity.Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses.New hope or drawbacks: will chronic kidney disease be treatable with small molecules in the near future?Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2).C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.Essential Role of Keap1-Nrf2 Signaling in Mood Disorders: Overview and Future Perspective
P2860
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P2860
Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Tricyclic compounds containing ...... tory and cytoprotective agents
@ast
Tricyclic compounds containing ...... tory and cytoprotective agents
@en
type
label
Tricyclic compounds containing ...... tory and cytoprotective agents
@ast
Tricyclic compounds containing ...... tory and cytoprotective agents
@en
prefLabel
Tricyclic compounds containing ...... tory and cytoprotective agents
@ast
Tricyclic compounds containing ...... tory and cytoprotective agents
@en
P2093
P2860
P356
P1476
Tricyclic compounds containing ...... tory and cytoprotective agents
@en
P2093
Bill D Roebuck
Chitra Sundararajan
Emilie David
Frank G Favaloro
Gordon W Gribble
Hidenori Yoshizawa
Marc J Lajoie
Tadashi Honda
Yukiko Honda
P2860
P304
P356
10.1021/JM101445P
P407
P577
2011-03-01T00:00:00Z