Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179. - Wikidata - wikimedia - TriplyDB

Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.

Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.

http://www.wikidata.org/entity/Q34568528

about

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress Effect of redox modulating NRF2 activators on chronic kidney disease Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction When NRF2 talks, who's listening?Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response The complexity of the Nrf2 pathway: beyond the antioxidant response Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization.High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma.Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.N-acetylcysteine, reactive oxygen species and beyond.The triterpenoid CDDO-Me delays murine acute graft-versus-host disease with the preservation of graft-versus-tumor effects after allogeneic bone marrow transplantation.Determining Cysteines Available for Covalent Inhibition Across the Human Kinome.CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells.Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.Induction of Apoptosis in Pancreatic Cancer Cells by CDDO-Me Involves Repression of Telomerase through Epigenetic Pathways.Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases.The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas.Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound.Discontinued in 2013: diabetic drugs.Trichothecin induces cell death in NF-κB constitutively activated human cancer cells via inhibition of IKKβ phosphorylation.Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3 Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development 2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinase Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity.Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells.Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.Therapeutic effects of C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me; bardoxolone methyl) on radiation-induced lung inflammation and fibrosis in mice.Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.

P2860

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P2860

Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.

http://www.wikidata.org/entity/Q34568528

description

2006 nî lūn-bûn

@nan

2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.

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Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.

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Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.

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type

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Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.

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Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.

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Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.

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prefLabel

Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.

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Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.

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Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.

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P1433

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P1433

Journal of Biological Chemistry

P1476

Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.

@en

P2093

Colin Meyer

http://www.w3.org/2001/XMLSchema#string

Deepak Raina

http://www.w3.org/2001/XMLSchema#string

Donald Kufe

http://www.w3.org/2001/XMLSchema#string

Rehan Ahmad

http://www.w3.org/2001/XMLSchema#string

Surender Kharbanda

http://www.w3.org/2001/XMLSchema#string

P2860

Reactive oxygen special (ROS), troublemakers between nuclear factor-kB (NF-kB) and c-Jun NH2-terminal kinase (JNK)

Binding of manumycin A inhibits IkappaB kinase beta activity

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

Signaling to NF-kappaB

NF-kappaB in cancer: from innocent bystander to major culprit

Ubiquitin signalling in the NF-kappaB pathway

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase.

Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents.

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

P304

35764-35769

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scholarly article

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10.1074/JBC.M607160200

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47

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P478

281

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2006-09-24T00:00:00Z

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16998237

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