Differential effects of targeting Notch receptors in a mouse model of liver cancer. - Wikidata - wikimedia - TriplyDB

Differential effects of targeting Notch receptors in a mouse model of liver cancer.

Differential effects of targeting Notch receptors in a mouse model of liver cancer.

http://www.wikidata.org/entity/Q35660341

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C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling Notch signaling: its roles and therapeutic potential in hematological malignancies Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model.Combinatorial interventions inhibit TGFβ-driven epithelial-to-mesenchymal transition and support hybrid cellular phenotypes.Actin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition.Prognostic significance and anti-proliferation effect of microRNA-365 in hepatocellular carcinoma.Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of miR-148a on tumor growth and phenotype and liver fibrosis.Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects.ADAM Proteases and Gastrointestinal Function.Notch3 drives development and progression of cholangiocarcinoma.Molecular and proteomic insight into Notch1 characterization in hepatocellular carcinoma.Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans.Transgenic mouse models generated by hydrodynamic transfection for genetic studies of liver cancer and preclinical testing of anti-cancer therapy.The complex role of NOTCH receptors and their ligands in the development of hepatoblastoma, cholangiocarcinoma and hepatocellular carcinoma.Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).MicroRNA-608 acts as a prognostic marker and inhibits the cell proliferation in hepatocellular carcinoma by macrophage migration inhibitory factor.Notch Signaling Components: Diverging Prognostic Indicators in Lung Adenocarcinoma.Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives.Role of the Notch signaling in cholangiocarcinoma.Biliary cancer: intrahepatic cholangiocarcinoma vs. extrahepatic cholangiocarcinoma vs. gallbladder cancers: classification and therapeutic implications.Effect of prolyl hydroxylase domain 2 haplodeficiency on liver progenitor cell characteristics in early mouse hepatocarcinogenesis Notch Signaling in Development, Tissue Homeostasis, and Disease.Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation.Analysis of microarrays of miR-34a and its identification of prospective target gene signature in hepatocellular carcinoma.Notch signaling and progenitor/ductular reaction in steatohepatitis.The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone.Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation: Impact on Regulation of Notch Pathway.Hippo cascade controls lineage commitment of liver tumors in mice and humans.An Antibody to Notch2 Reverses the Osteopenic Phenotype of Hajdu-Cheney Mutant Male Mice.Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study.Understanding liver regeneration to bring new insights to the mechanisms driving cholangiocarcinoma.Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice.Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2 mice and human cholangiocarcinoma tumorigenesis Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming

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P2860

Differential effects of targeting Notch receptors in a mouse model of liver cancer.

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Differential effects of targeting Notch receptors in a mouse model of liver cancer.

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Christian W Siebel

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Dorothy M French

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Erik G Huntzicker

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Neeraj Sharma

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Xin Chen

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Therapeutic antibody targeting of individual Notch receptors

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

Initial activation of EpCAM cleavage via cell-to-cell contact.

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

Cholangiocarcinomas can originate from hepatocytes in mice.

Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice

Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma

Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells.

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