Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells. - Wikidata - wikimedia - TriplyDB

Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells.

Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells.

http://www.wikidata.org/entity/Q37220370

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Notch signaling in prostate cancer: refining a therapeutic opportunity Targeting CSC-related miRNAs for cancer therapy by natural agents A multi-targeted approach to suppress tumor-promoting inflammation Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment MiR-370 sensitizes chronic myeloid leukemia K562 cells to homoharringtonine by targeting Forkhead box M1 7-difluoromethoxyl-5,4'-di-n-octyl genistein inhibits ovarian cancer stem cell characteristics through the downregulation of FOXM1.Notch inhibitors for cancer treatment.Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells The pathological significance of Notch1 in oral squamous cell carcinoma.Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells Protein-coding and microRNA biomarkers of recurrence of prostate cancer following radical prostatectomy Sorafenib inhibits proliferation and invasion of human hepatocellular carcinoma cells via up-regulation of p53 and suppressing FoxM1.Notch-1 signaling promotes the malignant features of human breast cancer through NF-κB activation Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells.Induction of cancer cell death by isoflavone: the role of multiple signaling pathways.Differential effects of targeting Notch receptors in a mouse model of liver cancer.Investigation of FOXM1 as a Potential New Target for Melanoma.Estradiol meets notch signaling in developing neurons.Correlation of Notch1, pAKT and nuclear NF-κB expression in triple negative breast cancer.Novel strategies targeting cancer stem cells through phytochemicals and their analogs The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness.Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells.Notch4 inhibition reduces migration and invasion and enhances sensitivity to docetaxel by inhibiting Akt/fascin in pancreatic cancer cells.The roles of FOXM1 in pancreatic stem cells and carcinogenesis Hypoxia, notch signalling, and prostate cancer.NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.Targeting CSCs within the tumor microenvironment for cancer therapy: a potential role of mesenchymal stem cells.The strategies to control prostate cancer by chemoprevention approaches.Notch signaling in the prostate: critical roles during development and in the hallmarks of prostate cancer biology.Notch-1 signaling activates NF-κB in human breast carcinoma MDA-MB-231 cells via PP2A-dependent AKT pathway.Down regulation of CSL activity inhibits cell proliferation in prostate and breast cancer cells.Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model Elevated Jagged-1 and Notch-1 expression in high grade and metastatic prostate cancers.Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer.Notch 1 is a valuable therapeutic target against cell survival and proliferation in clear cell renal cell carcinoma.No evidence for induction of key components of the Notch signaling pathway (Notch-1, Jagged-1) by treatment with UV-B, 1,25(OH)(2)D(3), and/or epigenetic drugs (TSA, 5-Aza) in human keratinocytes in vitro.High FOXM1 expression was associated with bladder carcinogenesis.Increased expression of forkhead box M1 protein is associated with poor prognosis in clear cell renal cell carcinoma.Notch1 cardioprotection in myocardial ischemia/reperfusion involves reduction of oxidative/nitrative stress.CSL regulates AKT to mediate androgen independence in prostate cancer progression.

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Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells.

http://www.wikidata.org/entity/Q37220370

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scientific article published on January 2011

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Down-regulation of Notch-1 is ...... osis in prostate cancer cells.

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Down-regulation of Notch-1 is ...... osis in prostate cancer cells.

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Down-regulation of Notch-1 is ...... osis in prostate cancer cells.

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Down-regulation of Notch-1 is ...... osis in prostate cancer cells.

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Down-regulation of Notch-1 is ...... osis in prostate cancer cells.

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Down-regulation of Notch-1 is ...... osis in prostate cancer cells.

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Journal of Cellular Biochemistry

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Down-regulation of Notch-1 is ...... osis in prostate cancer cells.

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Aamir Ahmad

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Christine Wojewoda

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Dejuan Kong

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Fazlul H Sarkar

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Lucio Miele

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Sanjeev Banerjee

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Yiwei Li

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Zhiwei Wang

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P2860

FoxM1, a critical regulator of oxidative stress during oncogenesis

Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice

Increased expression of integrin-linked kinase is associated with shorter survival in non-small cell lung cancer

Gene expression profiling revealed novel mechanism of action of Taxotere and Furtulon in prostate cancer cells

Down-regulation of Forkhead Box M1 transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells

Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators

Cancer statistics, 2009

The canonical Notch signaling pathway: unfolding the activation mechanism.

Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process.

Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancer.

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78-88

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scholarly article

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10.1002/JCB.22770

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1

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112

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Fazlul H. Sarkar

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2011-01-01T00:00:00Z

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20658545

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apoptotic process

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3792569

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