An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. - Wikidata - wikimedia - TriplyDB

An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.

An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.

http://www.wikidata.org/entity/Q35669634

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Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons Botulinum neurotoxin serotype A specific cell-based potency assay to replace the mouse bioassay Enhanced neutralization potency of botulinum neurotoxin antibodies using a red blood cell-targeting fusion protein Small molecules showing significant protection of mice against botulinum neurotoxin serotype A Epitope targeting of tertiary protein structure enables target-guided synthesis of a potent in-cell inhibitor of botulinum neurotoxin.Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency.Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain Neutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain.Botulinum neurotoxin devoid of receptor binding domain translocates active protease.Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation.Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries Toosendanin: synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II).Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions A high-throughput-compatible FRET-based platform for identification and characterization of botulinum neurotoxin light chain modulators Discovery libraries targeting the major enzyme classes: the serine hydrolases.Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library.The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.Analysis of Botulinum Neurotoxin Serotype A Metalloprotease Inhibitors: Analogs of a Chemotype for Therapeutic Development in the Context of a Three-Zone Pharmacophore Symptomatic relief of botulinum neurotoxin/a intoxication with aminopyridines: a new twist on an old molecule.Small-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice.High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research Basic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity.Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors Capsaicin protects mouse neuromuscular junctions from the neuroparalytic effects of botulinum neurotoxin a Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.Enhancing the Pharmacokinetic Properties of Botulinum Neurotoxin Serotype A Protease Inhibitors Through Rational Design The zinc-dependent protease activity of the botulinum neurotoxins Cleavage of SNAP25 and its shorter versions by the protease domain of serotype A botulinum neurotoxin.Functional evaluation of biological neurotoxins in networked cultures of stem cell-derived central nervous system neurons Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing.Cargo-delivery platforms for targeted delivery of inhibitor cargos against botulism.Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B.Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.

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An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.

http://www.wikidata.org/entity/Q35669634

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

An in vitro and in vivo discon ...... inum neurotoxin A antagonists.

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An in vitro and in vivo discon ...... inum neurotoxin A antagonists.

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An in vitro and in vivo discon ...... inum neurotoxin A antagonists.

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An in vitro and in vivo discon ...... inum neurotoxin A antagonists.

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An in vitro and in vivo discon ...... inum neurotoxin A antagonists.

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An in vitro and in vivo discon ...... inum neurotoxin A antagonists.

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Proceedings of the National Academy of Sciences of the United States of America

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An in vitro and in vivo discon ...... linum neurotoxin A antagonists

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Carl J Malizio

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Colin M Clancy

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Dale L Boger

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Eric A Johnson

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Joseph T Barbieri

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Kim D Janda

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Lisa M Eubanks

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Tobin J Dickerson

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P2860

Properties and use of botulinum toxin and other microbial neurotoxins in medicine

Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution

Crystal structure of botulinum neurotoxin type A and implications for toxicity

Principles of protein-protein interactions

Shape complementarity at protein/protein interfaces

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

The atomic structure of protein-protein recognition sites

Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps

Proteolysis of SNAP-25 by types E and A botulinal neurotoxins

Unraveling hot spots in binding interfaces: progress and challenges

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104

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Michael R Baldwin

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