Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.
about
Sequence alterations within CYP7B1 implicate defective cholesterol homeostasis in motor-neuron degenerationThe bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasisHuman CYP7A1 deficiency: progress and enigmasIdentification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver diseaseCyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenoloneCytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eyeDown-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestineNrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitisCarboxylesterase1/Esterase-x regulates chylomicron production in miceProtein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestineDecreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient miceDisturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse modelEndothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in miceElevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channelsActivities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathwaysChronic intermittent psychological stress promotes macrophage reverse cholesterol transport by impairing bile acid absorption in mice.CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functionsInactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice.Disruption of retinoblastoma protein expression in the intestinal epithelium impairs lipid absorptionBile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1cMice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet.Analysis of organ physiology in transgenic mice.Human risk allele HLA-DRB1*0405 predisposes class II transgenic Ab0 NOD mice to autoimmune pancreatitis.Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms.Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism.Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serumTis7 deletion reduces survival and induces intestinal anastomotic inflammation and obstruction in high-fat diet-fed mice with short bowel syndrome.Deletion of Tis7 protects mice from high-fat diet-induced weight gain and blunts the intestinal adaptive response postresection.A functional C-G polymorphism in the CYP7B1 promoter region and its different distribution in Orientals and Caucasians.Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA.Structural and dynamic basis of human cytochrome P450 7B1: a survey of substrate selectivity and major active site access channels.Cholic acid mediates negative feedback regulation of bile acid synthesis in mice.Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.P2Y13 receptor regulates HDL metabolism and atherosclerosis in vivoOstα-/- mice are not protected from western diet-induced weight gainThe effect of impaired angiogenesis on intestinal function following massive small bowel resection.Primary hypercholesterolemia: genetic causes and treatment of five monogenic disorders.
P2860
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P2860
Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Disruption of cholesterol 7alp ...... oxysterol 7alpha-hydroxylase.
@ast
Disruption of cholesterol 7alp ...... oxysterol 7alpha-hydroxylase.
@en
type
label
Disruption of cholesterol 7alp ...... oxysterol 7alpha-hydroxylase.
@ast
Disruption of cholesterol 7alp ...... oxysterol 7alpha-hydroxylase.
@en
prefLabel
Disruption of cholesterol 7alp ...... oxysterol 7alpha-hydroxylase.
@ast
Disruption of cholesterol 7alp ...... oxysterol 7alpha-hydroxylase.
@en
P2093
P2860
P50
P356
P1476
Disruption of cholesterol 7alp ...... f oxysterol 7alpha-hydroxylase
@en
P2093
P2860
P304
18024-18031
P356
10.1074/JBC.271.30.18024
P407
P577
1996-07-01T00:00:00Z