about
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolismExpression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterolThe bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasisDefinition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesisActivation of the nuclear receptor LXR by oxysterols defines a new hormone response pathwayGlucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytesStructural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbetaIdentification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver diseaseEndocrine fibroblast growth factors 15/19 and 21: from feast to famineResveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life spanBile acids: regulation of apoptosis by ursodeoxycholic acidCPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase geneDifferential modulation of cellular death and survival pathways by conjugated bile acidsGut Microbiota Profiling: Metabolomics Based Approach to Unravel Compounds Affecting Human HealthRole of bile acids in the regulation of the metabolic pathwaysBile Acid Metabolism and Signaling in Cholestasis, Inflammation, and CancerCrystal Structure of Human Liver 4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and CatalysisStructure and catalytic mechanism of human steroid 5β-reductase (AKR1D1)Conversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERINGCytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholateAssociation of CYP7A1 -278A>C polymorphism and the response of plasma triglyceride after dietary intervention in dyslipidemic patientsThe binding of cholesterol and bile salts to recombinant rat liver fatty acid-binding proteinMonogenic dyslipidemias: window on determinants of plasma lipoprotein metabolismSuppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytesPhysical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoterThe role of alpha-methylacyl-CoA racemase in bile acid synthesisDisturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse modelElevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic networkThe murine and human cholesterol 7alpha-hydroxylase gene promoters are differentially responsive to regulation by fatty acids mediated via peroxisome proliferator-activated receptor alphaMonascus purpureus-fermented Thai glutinous rice reduces blood and hepatic cholesterol and hepatic steatosis concentrations in diet-induced hypercholesterolemic rats.The potential role of HMG-CoA reductase inhibitors in pediatric nephrotic syndrome.Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesisEffect of Cyp27A1 gene dosage on atherosclerosis development in ApoE-knockout mice.Circadian signatures in rat liver: from gene expression to pathways.Piperine potentiates the hypocholesterolemic effect of curcumin in rats fed on a high fat dietRegulation of cytochrome P450 (CYP) genes by nuclear receptors.Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR elementHepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.
P2860
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P2860
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Bile acid biosynthesis.
@ast
Bile acid biosynthesis.
@en
type
label
Bile acid biosynthesis.
@ast
Bile acid biosynthesis.
@en
prefLabel
Bile acid biosynthesis.
@ast
Bile acid biosynthesis.
@en
P356
P1433
P1476
Bile acid biosynthesis.
@en
P2093
Russell DW
Setchell KD
P304
P356
10.1021/BI00135A001
P407
P577
1992-05-01T00:00:00Z