Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase - Wikidata - wikimedia - TriplyDB

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

http://www.wikidata.org/entity/Q35676802

about

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2 The ubiquitin proteasome system in neuropathology Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint Maintaining Genome Stability in Defiance of Mitotic DNA Damage Aurora Kinase Inhibitors: Current Status and Outlook Phenotypic Screening Approaches to Develop Aurora Kinase Inhibitors: Drug Discovery Perspectives Aurora kinase A in gastrointestinal cancers: time to target TACC3 Is Important for Correct Progression of Meiosis in Bovine Oocytes A Cell Biologist's Field Guide to Aurora Kinase Inhibitors Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design Development of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors Crystal Structure of Human Aurora B in Complex with INCENP and VX-680 Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells Non ionising radiation as a non chemical strategy in regenerative medicine: Ca(2+)-ICR "In Vitro" effect on neuronal differentiation and tumorigenicity modulation in NT2 cells Inhibition of Aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases R763/AS703569 and PHA-739358 in BCR-ABL transformed cells Aurora kinase-A deficiency during skin development impairs cell division and stratification Aurora A is essential for early embryonic development and tumor suppression Identification of Aurora-A Inhibitors by Ligand and Structure-Based Virtual Screening.Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy.Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization.Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis.Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells.A current review of targeted therapeutics for ovarian cancer.Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells.Aurora kinase inhibitors--rising stars in cancer therapeutics?In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors A phase I dose-escalation study of danusertib (PHA-739358) administered as a 24-hour infusion with and without granulocyte colony-stimulating factor in a 14-day cycle in patients with advanced solid tumors.Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions

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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

http://www.wikidata.org/entity/Q35676802

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2007 nî lūn-bûn

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2007年の論文

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Antitumor activity of MLN8054, ...... e inhibitor of Aurora A kinase

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Antitumor activity of MLN8054, ...... e inhibitor of Aurora A kinase

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Antitumor activity of MLN8054, ...... e inhibitor of Aurora A kinase

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Antitumor activity of MLN8054, ...... e inhibitor of Aurora A kinase

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Antitumor activity of MLN8054, ...... e inhibitor of Aurora A kinase

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Antitumor activity of MLN8054, ...... e inhibitor of Aurora A kinase

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PNAS.0608798104

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Proceedings of the National Academy of Sciences of the United States of America

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Antitumor activity of MLN8054, ...... e inhibitor of Aurora A kinase

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Bradley Stringer

http://www.w3.org/2001/XMLSchema#string

Christopher F Claiborne

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Deborah R Wysong

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Emily T Ray

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Gabriel S Weatherhead

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Jeffrey A Ecsedy

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Jessica J Huck

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Joseph B Bolen

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Kara M Hoar

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Katherine M Galvin

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P2860

Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Mitotic kinases as regulators of cell division and its checkpoints

Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation

Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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10.1073/PNAS.0608798104

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10

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104

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2007-02-23T00:00:00Z

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6447702

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17360485

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1820716

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