Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation.
about
Developing Combined HIV Vaccine Strategies for a Functional CureProgrammed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load.Immune activation and HIV persistence: implications for curative approaches to HIV infection.Autologous HIV-1 clade-B Nef peptides elicit increased frequency, breadth and function of CD8+ T-cells compared to consensus peptides.Rapid perturbation in viremia levels drives increases in functional avidity of HIV-specific CD8 T cells.Prolonged Antiretroviral Therapy Preserves HIV-1-Specific CD8 T Cells with Stem Cell-Like PropertiesCutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS.Increased sequence coverage through combined targeting of variant and conserved epitopes correlates with control of HIV replication.The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes.Functional avidity: a measure to predict the efficacy of effector T cells?Long-Term Non-Progression and Broad HIV-1-Specific Proliferative T-Cell Responses.PD-1 coinhibitory signals: the link between pathogenesis and protection.Unravelling the mechanisms of durable control of HIV-1.Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection.Kill: boosting HIV-specific immune responses.T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone.The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function.Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infectionImmunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire.The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8⁺ T cell responses.Wake me up before you go: A strategy to reduce the latent HIV reservoir.Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease.A Fixed Spatial Structure of CD8 T Cells in Tissue during Chronic HSV-2 InfectionPhenotype, Polyfunctionality, and Antiviral Activity of Stimulated CD8 T-Cells From HIV Subjects Who Initiated cART at Different Time-Points After Acute Infection
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P2860
Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Clonotype and repertoire chang ...... limited antigenic stimulation.
@ast
Clonotype and repertoire chang ...... limited antigenic stimulation.
@en
type
label
Clonotype and repertoire chang ...... limited antigenic stimulation.
@ast
Clonotype and repertoire chang ...... limited antigenic stimulation.
@en
prefLabel
Clonotype and repertoire chang ...... limited antigenic stimulation.
@ast
Clonotype and repertoire chang ...... limited antigenic stimulation.
@en
P2093
P2860
P50
P356
P1476
Clonotype and repertoire chang ...... limited antigenic stimulation.
@en
P2093
Abdelali Filali-Mouhim
Daniel C Douek
David R Ambrozak
Glenda Canderan
Jean-Pierre Routy
Loury Janbazian
Mohamad Rachid Boulassel
Richard A Koup
Tedi E Asher
P2860
P304
P356
10.4049/JIMMUNOL.1102610
P407
P577
2011-12-30T00:00:00Z