Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.
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New viruses for cancer therapy: meeting clinical needsTaking Gene Therapy into the ClinicAdenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice.Bacterial Cytosine Deaminase Mutants Created by Molecular Engineering Show Improved 5-Fluorocytosine-Mediated Cell Killing In vitro and In vivoThree-Dimensional Structure and Catalytic Mechanism of Cytosine DeaminaseProgress and problems with the use of suicide genes for targeted cancer therapyGanciclovir-mediated in vivo elimination of myeloid leukemic cells expressing the HSVtk gene induces HSVtk loss variants.Prodrug converting enzyme gene delivery by L. monocytogenes.Human nerual stem cells for brain repairOncolysis using herpes simplex virus type 1 engineered to express cytosine deaminase and a fusogenic glycoprotein for head and neck squamous cell carcinoma.Expression of the bifunctional suicide gene CDUPRT increases radiosensitization and bystander effect of 5-FC in prostate cancer cells.Genetically engineered HSV in the treatment of glioma: a review.HSVtk/GCV system on hepatoma carcinoma cells: Construction of the plasmid pcDNA3.1‑pAFP-TK and targeted killing effectProdrug-activating systems in suicide gene therapy.Prodrug activation enzymes in cancer gene therapy.Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives.Development of inhibitor-directed enzyme prodrug therapy (IDEPT) for prostate cancer.Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapyTumour-selective Salmonella-based cancer therapy.Gene therapy for high grade gliomas.Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase.Oncosuppressive suicide gene virotherapy "PVH1-yCD/5-FC" for pancreatic peritoneal carcinomatosis treatment: NFκB and Akt/PI3K involvementAssessment of α-fetoprotein targeted HSV1-tk expression in hepatocellular carcinoma with in vivo imaging.Prodrugs for improving tumor targetability and efficiency.Comparative analysis of enzyme and pathway engineering strategies for 5FC-mediated suicide gene therapy applications.Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide geneGene therapy and targeted toxins for glioma.Subcutaneous or intrahepatic injection of suicide gene modified tumour cells induces a systemic antitumour response in a metastatic model of colon carcinoma in ratsBrain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vectorTargeting of melanoma brain metastases using engineered neural stem/progenitor cellsNeural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomasGene therapy strategies to improve the effectiveness of cancer radiotherapy.Tumor-activated prodrugs--a new approach to cancer therapy.Gene- and immunotherapy for hepatocellular carcinoma.TK gene combined with mIL-2 and mGM-CSF genes in treatment of gastric cancerGene-directed enzyme prodrug therapy: a review of enzyme/prodrug combinations.Three-dimensional assessment of bystander effects of mesenchymal stem cells carrying a cytosine deaminase gene on glioma cells.Targeted cytosine deaminase-uracil phosphoribosyl transferase suicide gene therapy induces small cell lung cancer-specific cytotoxicity and tumor growth delay.Targeting mesothelioma using an infectivity enhanced survivin-conditionally replicative adenovirusesBifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model.
P2860
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P2860
Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Metabolism of 5-fluorocytosine ...... ls express cytosine deaminase.
@ast
Metabolism of 5-fluorocytosine ...... ls express cytosine deaminase.
@en
type
label
Metabolism of 5-fluorocytosine ...... ls express cytosine deaminase.
@ast
Metabolism of 5-fluorocytosine ...... ls express cytosine deaminase.
@en
prefLabel
Metabolism of 5-fluorocytosine ...... ls express cytosine deaminase.
@ast
Metabolism of 5-fluorocytosine ...... ls express cytosine deaminase.
@en
P2093
P2860
P356
P1476
Metabolism of 5-fluorocytosine ...... ls express cytosine deaminase.
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.17.8302
P407
P577
1994-08-01T00:00:00Z