A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities.
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Therapeutic Implications of Targeting AKT Signaling in MelanomaAkt1 in endothelial cell and angiogenesisThe critical role of Akt in cardiovascular functionProliferation and apoptosis in mammary epithelium during the rat oestrous cycleDownregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell LinesIn vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosineAkt1 in the cardiovascular system: friend or foe?Detection of functional single-nucleotide polymorphisms that affect apoptosisEffects of celecoxib and ly117018 combination on human breast cancer cells in vitro.Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle.Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells.The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum.Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.Functional and therapeutic significance of Akt deregulation in malignant melanoma.Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family.PERK-dependent regulation of IAP translation during ER stress.Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the PH domain of protein kinase Balpha.Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug.NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiologyTargeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximabThe PTEN-AKT3 signaling cascade as a therapeutic target in melanoma.Mitochondrial nitric oxide synthase: a masterpiece of metabolic adaptation, cell growth, transformation, and death.Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma.Recent development of anticancer therapeutics targeting Akt.Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding.The Akt isoforms, their unique functions and potential as anticancer therapeutic targets.Identification of AKT kinases as unfavorable prognostic factors for hepatocellular carcinoma by a combination of expression profile, interaction network analysis and clinical validation.Differential effects of AKT1(p.E17K) expression on human mammary luminal epithelial and myoepithelial cells.Akt2 interacts with Snail1 in the E-cadherin promoter.Involvement of Pin1 induction in epithelial-mesenchymal transition of tamoxifen-resistant breast cancer cells.Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition.Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549.High-resolution array CGH defines critical regions and candidate genes for microcephaly, abnormalities of the corpus callosum, and seizure phenotypes in patients with microdeletions of 1q43q44.Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domainRoles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines.Resistance to the Antiproliferative In Vitro Effect of PI3K-Akt-mTOR Inhibition in Primary Human Acute Myeloid Leukemia Cells Is Associated with Altered Cell Metabolism.A phase I, open-label, two-stage study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral AKT inhibitor GSK2141795 in patients with solid tumors.Transcriptional regulation of pro-apoptotic Par-4 by NF-kappaB/p65 and its function in controlling cell kinetics during early events in endometrial tumourigenesis.NDRG2 is involved in the oncogenic properties of renal cell carcinoma and its loss is a novel independent poor prognostic factor after nephrectomy.
P2860
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P2860
A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
A portrait of AKT kinases: hum ...... y with strong individualities.
@ast
A portrait of AKT kinases: hum ...... y with strong individualities.
@en
type
label
A portrait of AKT kinases: hum ...... y with strong individualities.
@ast
A portrait of AKT kinases: hum ...... y with strong individualities.
@en
prefLabel
A portrait of AKT kinases: hum ...... y with strong individualities.
@ast
A portrait of AKT kinases: hum ...... y with strong individualities.
@en
P2093
P356
P1476
A portrait of AKT kinases: hum ...... y with strong individualities.
@en
P2093
Alfonso Bellacosa
Joseph R Testa
Lionel Larue
Robert Moore
P304
P356
10.4161/CBT.3.3.703
P577
2004-03-11T00:00:00Z