Functional and therapeutic significance of Akt deregulation in malignant melanoma.
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Therapeutic Implications of Targeting AKT Signaling in MelanomaMelanoma: from mutations to medicineBreast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signalingPreclinical studies of celastrol and acetyl isogambogic acid in melanoma.Targeting Akt3 signaling in malignant melanoma using isoselenocyanates.AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1).Molecular pathogenesis of sporadic melanoma and melanoma-initiating cells.Akt1 deletion prevents lung tumorigenesis by mutant K-ras.The Role of B-RAF Mutations in Melanoma and the Induction of EMT via Dysregulation of the NF-κB/Snail/RKIP/PTEN CircuitChanges in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survivalAn allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo.The epithelial-mesenchymal transition (EMT) regulatory factor SLUG (SNAI2) is a downstream target of SPARC and AKT in promoting melanoma cell invasionThe antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradationTargeted therapy for melanoma: a primer.A phase I trial of bortezomib with temozolomide in patients with advanced melanoma: toxicities, antitumor effects, and modulation of therapeutic targets.Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathwaysThe T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis.Targeting sphingosine kinase-1 to inhibit melanoma.Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cellsTargeted agents for the treatment of metastatic melanoma.Therapeutic implications of targeting the PI3Kinase/AKT/mTOR signaling module in melanoma therapy.Targeted Therapies in Melanoma: Translational Research at Its Finest.The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2Melanoma prevention using topical PBISeInactivation of host Akt/protein kinase B signaling by bacterial pore-forming toxins.New approaches in metastatic melanoma: biological and molecular targeted therapies.The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias.Toxicogenomics of A375 human malignant melanoma cells.Targeting TGF-β1 inhibits invasion of anaplastic thyroid carcinoma cell through SMAD2-dependent S100A4-MMP-2/9 signalling.Growth factors and oncogenes as targets in melanoma: lost in translation?Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma.Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases.Reactive oxygen species: an Achilles' heel of melanoma?Use of liposomes as drug delivery vehicles for treatment of melanoma.Genetics and genomics of melanoma.PTEN: new insights into its regulation and function in skin cancer.Metastatic melanoma - a review of current and future drugsThe PTEN-AKT3 signaling cascade as a therapeutic target in melanoma.Melanoma biomarkers: current status and utility in diagnosis, prognosis, and response to therapy.
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P2860
Functional and therapeutic significance of Akt deregulation in malignant melanoma.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Functional and therapeutic significance of Akt deregulation in malignant melanoma.
@ast
Functional and therapeutic significance of Akt deregulation in malignant melanoma.
@en
type
label
Functional and therapeutic significance of Akt deregulation in malignant melanoma.
@ast
Functional and therapeutic significance of Akt deregulation in malignant melanoma.
@en
prefLabel
Functional and therapeutic significance of Akt deregulation in malignant melanoma.
@ast
Functional and therapeutic significance of Akt deregulation in malignant melanoma.
@en
P2860
P1476
Functional and therapeutic significance of Akt deregulation in malignant melanoma
@en
P2093
Gavin P Robertson
P2860
P2888
P304
P356
10.1007/S10555-005-1577-9
P577
2005-06-01T00:00:00Z