Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. - Wikidata - wikimedia - TriplyDB

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

http://www.wikidata.org/entity/Q35725108

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Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells β-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreas Reprogramming pancreatic cells to β cells Translational implications of the β-cell epigenome in diabetes mellitus Control of cell identity in pancreas development and regeneration Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells Stereological analyses of the whole human pancreas.Transcription factor regulation of pancreatic organogenesis, differentiation and maturation Epigenetic Regulation of Islet Development and Regeneration Arx is required for normal enteroendocrine cell development in mice and humans Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis Expression of Groucho/TLE proteins during pancreas development Adult tissue sources for new β cells.A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation.Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors.Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells Mesenchymal stem cell therapy in type 2 diabetes mellitus.Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage Xenopus pancreas development Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.Small-molecule inducers of insulin expression in pancreatic alpha-cells.Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice.Turning straw into gold: directing cell fate for regenerative medicine.Transcriptional regulation of α-cell differentiation.The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas Aristaless-related homeobox plays a key role in hyperplasia of the pancreas islet α-like cells in mice deficient in proglucagon-derived peptides Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3.Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass.Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas.An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice

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P2860

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

http://www.wikidata.org/entity/Q35725108

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Embryonic endocrine pancreas a ...... otypes upon Arx misexpression.

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Embryonic endocrine pancreas a ...... otypes upon Arx misexpression.

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Embryonic endocrine pancreas a ...... otypes upon Arx misexpression.

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P1433

Journal of Clinical Investigation

P1476

Embryonic endocrine pancreas a ...... notypes upon Arx misexpression

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P2093

Ahmed Mansouri

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Dietmar Riedel

http://www.w3.org/2001/XMLSchema#string

Jacob Hecksher-Sørensen

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Jens Krull

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P2860

neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

Notch signalling controls pancreatic cell differentiation

Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

P304

961-970

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scholarly article

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10.1172/JCI29115

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P433

4

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117

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Patrick Collombat

Pedro Luis Herrera

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2007-04-01T00:00:00Z

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51386053

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17404619

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P921

Aizkuņģa dziedzeris

P932

1839241

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