Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.
about
Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor populationThe ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cellsβ-Cell regeneration through the transdifferentiation of pancreatic cells: Pancreatic progenitor cells in the pancreasReprogramming pancreatic cells to β cellsTranslational implications of the β-cell epigenome in diabetes mellitusControl of cell identity in pancreas development and regenerationPancreatic α-cell specific deletion of mouse Arx leads to α-cell identity lossThe inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cellsStereological analyses of the whole human pancreas.Transcription factor regulation of pancreatic organogenesis, differentiation and maturationEpigenetic Regulation of Islet Development and RegenerationArx is required for normal enteroendocrine cell development in mice and humansProx1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesisExpression of Groucho/TLE proteins during pancreas developmentAdult tissue sources for new β cells.A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairmentReconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation.Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors.Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cellsMesenchymal stem cell therapy in type 2 diabetes mellitus.Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineageXenopus pancreas developmentReversible changes in pancreatic islet structure and function produced by elevated blood glucose.Small-molecule inducers of insulin expression in pancreatic alpha-cells.Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice.Turning straw into gold: directing cell fate for regenerative medicine.Transcriptional regulation of α-cell differentiation.The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in miceHistorical perspective: beginnings of the beta-cell: current perspectives in beta-cell developmentNkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreasAristaless-related homeobox plays a key role in hyperplasia of the pancreas islet α-like cells in mice deficient in proglucagon-derived peptidesIslet-1 regulates Arx transcription during pancreatic islet alpha-cell developmentMaturation of stem cell-derived beta-cells guided by the expression of urocortin 3.Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass.Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas.An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice
P2860
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P2860
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Embryonic endocrine pancreas a ...... otypes upon Arx misexpression.
@ast
Embryonic endocrine pancreas a ...... otypes upon Arx misexpression.
@en
type
label
Embryonic endocrine pancreas a ...... otypes upon Arx misexpression.
@ast
Embryonic endocrine pancreas a ...... otypes upon Arx misexpression.
@en
prefLabel
Embryonic endocrine pancreas a ...... otypes upon Arx misexpression.
@ast
Embryonic endocrine pancreas a ...... otypes upon Arx misexpression.
@en
P2093
P2860
P50
P356
P1476
Embryonic endocrine pancreas a ...... notypes upon Arx misexpression
@en
P2093
Ahmed Mansouri
Dietmar Riedel
Jacob Hecksher-Sørensen
Jens Krull
P2860
P304
P356
10.1172/JCI29115
P407
P577
2007-04-01T00:00:00Z