Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer - Wikidata - wikimedia - TriplyDB

Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer

Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer

http://www.wikidata.org/entity/Q35747590

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Li-fraumeni syndrome Genetic variability in MCF-7 sublines: evidence of rapid genomic and RNA expression profile modifications Emerging Role of Genomic Rearrangements in Breast Cancer: Applying Knowledge from Other Cancers The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells Expression changes of the MAD mitotic checkpoint gene family in renal cell carcinomas characterized by numerical chromosome changes Overexpression of centromere protein H is significantly associated with breast cancer progression and overall patient survival.BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells.Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancer A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation.SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.Losing balance: the origin and impact of aneuploidy in cancer BUB1 mediation of caspase-independent mitotic death determines cell fate.The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation Tamoxifen-stimulated growth of breast cancer due to p21 loss Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells.Image analysis of the AgNOR response in ras-transformed human breast epithelial cells P21 gene knock down does not identify genetic effectors seen with gene knock out.Mechanisms of chromosomal instability.Identification of possible genetic alterations in the breast cancer cell line MCF-7 using high-density SNP genotyping microarray.Studying chromosome instability in the mouse.Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro Genetic instability: tipping the balance.Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines.A cell-based assay for screening spindle checkpoint inhibitors Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture.The ultrastructure of MCF-10A acini.Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells.Synuclein gamma inhibits the mitotic checkpoint function and promotes chromosomal instability of breast cancer cells.The mitotic spindle checkpoint is a critical determinant for topoisomerase-based chemotherapy.Expression of mitotic-arrest deficiency 2 predicts the efficacy of neoadjuvant chemotherapy for locally advanced uterine cervical cancer.Mitotic arrest deficiency 2 induces carcinogenesis in mucinous ovarian tumors.Identification of Staphylococcus aureus α-hemolysin as a protein drug that is secreted by anticancer bacteria and rapidly kills cancer cells.Base Excision Repair Variants in Cancer.Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation.Epothilones and new analogues of the microtubule modulators in taxane-resistant disease Speciation Theory of Carcinogenesis Explains Karyotypic Individuality and Long Latencies of Cancers

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P2860

Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer

http://www.wikidata.org/entity/Q35747590

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Variable levels of chromosomal ...... point defects in breast cancer

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Variable levels of chromosomal ...... point defects in breast cancer

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Variable levels of chromosomal ...... point defects in breast cancer

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S0002-9440(10)64194-6

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The American Journal of Pathology

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Variable levels of chromosomal ...... point defects in breast cancer

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P2093

Dae-Sung Yoon

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Edward Gabrielson

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Elizabeth S Garrett

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Francis J Chrest

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Robert P Wersto

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Teag Kyu Kwon

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Weibo Zhou

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P2860

Identification of a human mitotic checkpoint gene: hsMAD2

Mutations of mitotic checkpoint genes in human cancers

Genetic instability of cancer cells is proportional to their degree of aneuploidy

Genetic instabilities in human cancers

The clonal evolution of tumor cell populations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

Genetic instability in colorectal cancers

Recombinant, replication-defective adenovirus gene transfer vectors induce cell cycle dysregulation and inappropriate expression of cyclin proteins.

A mutator phenotype in cancer.

Chromosome instability contributes to loss of heterozygosity in mice lacking p53

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391-397

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10.1016/S0002-9440(10)64194-6

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1850727

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