Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.
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Gene-specific requirement of RNA polymerase II CTD phosphorylationElevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin ResistancePhosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genomePol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex.Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II.Phosphorylation of the yeast Rpb1 C-terminal domain at serines 2, 5, and 7.TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.Ssu72 phosphatase-dependent erasure of phospho-Ser7 marks on the RNA polymerase II C-terminal domain is essential for viability and transcription termination.Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes.Interactions of Sen1, Nrd1, and Nab3 with multiple phosphorylated forms of the Rpb1 C-terminal domain in Saccharomyces cerevisiae.Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA StabilizationThreonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongationRNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and TemplateZinc-regulated DNA binding of the yeast Zap1 zinc-responsive activator.TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape.Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTDFunctional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryosCDK8 is a positive regulator of transcriptional elongation within the serum response network.Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes.CDK7-dependent transcriptional addiction in triple-negative breast cancer.CDK8: a positive regulator of transcriptionThe Ssu72 phosphatase mediates the RNA polymerase II initiation-elongation transition.Roles of two activation domains in Zap1 in the response to zinc deficiency in Saccharomyces cerevisiae.PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth.Transcriptional regulation in Saccharomyces cerevisiae: transcription factor regulation and function, mechanisms of initiation, and roles of activators and coactivators.Emerging Views on the CTD CodeTHZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and PausingZinc-responsive coactivator recruitment by the yeast Zap1 transcription factor.Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modificationTranscriptional regulation of the Zrg17 zinc transporter of the yeast secretory pathway.Non-coding RNAs regulating the transcriptional machinery.TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeastPhosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii.The Paf1 complex: platform or player in RNA polymerase II transcription?Pause, play, repeat: CDKs push RNAP II's buttons.Chemical genetics: budding yeast as a platform for drug discovery and mapping of genetic pathways.Transcription inhibition as a therapeutic target for cancerChromatin modification by the RNA Polymerase II elongation complex.
P2860
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P2860
Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Chemical inhibition of the TFI ...... impair global mRNA synthesis.
@ast
Chemical inhibition of the TFI ...... impair global mRNA synthesis.
@en
type
label
Chemical inhibition of the TFI ...... impair global mRNA synthesis.
@ast
Chemical inhibition of the TFI ...... impair global mRNA synthesis.
@en
prefLabel
Chemical inhibition of the TFI ...... impair global mRNA synthesis.
@ast
Chemical inhibition of the TFI ...... impair global mRNA synthesis.
@en
P2093
P2860
P356
P1476
Chemical inhibition of the TFI ...... t impair global mRNA synthesis
@en
P2093
Agnes Viale
Aseem Z Ansari
Charles Kung
Elenita I Kanin
Kevan M Shokat
Matthew Slattery
Ryan T Kipp
P2860
P304
P356
10.1073/PNAS.0611505104
P407
P50
P577
2007-03-28T00:00:00Z