Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy
about
Peroxisomes in brain development and functionX-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management.Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies.ABCD2 alters peroxisome proliferator-activated receptor α signaling in vitro, but does not impair responses to fenofibrate therapy in a mouse model of diet-induced obesityCerebrospinal fluid matrix metalloproteinases are elevated in cerebral adrenoleukodystrophy and correlate with MRI severity and neurologic dysfunction.Histone deacetylase inhibitor upregulates peroxisomal fatty acid oxidation and inhibits apoptotic cell death in abcd1-deficient glial cells.Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy.ABCD1 deletion-induced mitochondrial dysfunction is corrected by SAHA: implication for adrenoleukodystrophy.Pioglitazone halts axonal degeneration in a mouse model of X-linked adrenoleukodystrophyOxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophyCaffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced mouse primary astrocytes.Recurrent subacute post-viral onset of ataxia associated with a PRF1 mutation.Signal transduction in inherited metabolic disorders: a model for a possible pathogenetic mechanism.S149R, a novel mutation in the ABCD1 gene causing X-linked adrenoleukodystrophy.Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency.Eight novel mutations in the ABCD1 gene and clinical characteristics of 25 Chinese patients with X-linked adrenoleukodystrophy.A zebrafish model of X-linked adrenoleukodystrophy recapitulates key disease features and demonstrates a developmental requirement for abcd1 in oligodendrocyte patterning and myelination.Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain.Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked adrenoleukodystrophy involves AMP-activated protein kinase.Therapeutic strategies in adrenoleukodystrophy.Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy.Modeling and rescue of defective blood-brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients.
P2860
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P2860
Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Functional genomic analysis un ...... erplay in adrenoleukodystrophy
@ast
Functional genomic analysis un ...... erplay in adrenoleukodystrophy
@en
type
label
Functional genomic analysis un ...... erplay in adrenoleukodystrophy
@ast
Functional genomic analysis un ...... erplay in adrenoleukodystrophy
@en
prefLabel
Functional genomic analysis un ...... erplay in adrenoleukodystrophy
@ast
Functional genomic analysis un ...... erplay in adrenoleukodystrophy
@en
P2093
P2860
P50
P356
P1476
Functional genomic analysis un ...... erplay in adrenoleukodystrophy
@en
P2093
Alistair McLaren
Ekaterina Ilieva
Fiona Kelly
Jorge Galino
Juliet Reid
Laia Morató
Lluís Espinosa
Muriel Asheuer
Patrick Aubourg
P2860
P304
P356
10.1093/HMG/DDR536
P577
2011-11-17T00:00:00Z