Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice.
about
The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer's disease phenotypeFLAP pharmacological blockade modulates metabolism of endogenous tau in vivo .Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein.Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidencePharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy.Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus.Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease.Gene Therapy Models of Alzheimer's Disease and Other Dementias.5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5.The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence.GATA1-mediated transcriptional regulation of the γ-secretase activating protein increases Aβ formation in Down syndrome.The 12-15-lipoxygenase is a modulator of Alzheimer's-related tau pathology in vivoNovel lipid signaling pathways in Alzheimer's disease pathogenesis.Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models.The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease.Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases.Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability.The 5-Lipoxygenase as modulator of Alzheimer's γ-secretase and therapeutic target.Commentary: Advancement of Knowledge of Brucella Over the Past 50 YearsThe direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy.Tactile stimulation during different developmental periods modifies hippocampal BDNF and GR, affecting memory and behavior in adult rats.Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy.Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice.
P2860
Q26999358-4747E63F-4DC3-4577-BBC1-3B2E3A78CDA5Q33647503-3B10A999-45B7-41BF-B06F-B6902F1AF643Q33844923-34EF9550-44F9-458E-816A-49AB400B57A2Q34650215-74AD940A-A6C0-4BED-A784-A34F62611384Q35745694-BD031250-6FD1-4EDD-A96B-72C9283BF983Q35929097-063DCEC4-3B54-40D6-BD84-7CF3784B6B81Q35991969-9632F1F7-C240-43D8-BEA3-04FC1604A54AQ36181709-D6CF9065-B32C-4121-9BBA-759D08406C73Q36299503-E30D1EED-33B5-4178-8E5F-66766C2504A2Q36524290-FADFB6DC-BB38-46C0-BF15-846ADD36A613Q36680982-447CDA65-C415-4BCE-9669-1532DCBBF8C3Q37053817-5E060055-FDCE-4546-8BEA-0F18CF8FCCA4Q37184747-88460725-2910-4873-8EFD-A5A62F051DF9Q37337281-B4CE72A9-0909-47A9-8D87-9D61AE4425AAQ37678676-31377304-B6B7-4619-9432-8F6C7B3D3A9EQ38044434-2BF704CF-EB83-46F5-9293-C53E4EFAC2D6Q38671719-A1DB26DB-C016-428C-8DBB-E671BCE00E55Q38728679-73927719-FD08-4056-AAB5-20A996911C4CQ38784992-D155B076-ECCC-45F7-814D-D558831DFE7AQ38785505-DE851635-205C-4145-8E57-D446A0BCE2B1Q41863415-712F501D-2BDB-473C-AAB4-01DAF28F0BDDQ47284015-E571D262-5466-4921-9E55-8C391EEDCFC3Q47369903-57DA47EA-FFCA-45F5-8D06-5F0DCE19DB75Q47412565-5DA9812F-CB40-4F6E-9F39-B4E144F6B17CQ47438369-451FDFED-6A6B-4507-ABE3-38F5757FD893
P2860
Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Adeno-associated virus-mediate ...... AD-like phenotype of APP mice.
@ast
Adeno-associated virus-mediate ...... AD-like phenotype of APP mice.
@en
type
label
Adeno-associated virus-mediate ...... AD-like phenotype of APP mice.
@ast
Adeno-associated virus-mediate ...... AD-like phenotype of APP mice.
@en
prefLabel
Adeno-associated virus-mediate ...... AD-like phenotype of APP mice.
@ast
Adeno-associated virus-mediate ...... AD-like phenotype of APP mice.
@en
P2093
P2860
P356
P1476
Adeno-associated virus-mediate ...... AD-like phenotype of APP mice.
@en
P2093
Carolina Ceballos-Diaz
Domenico Pratico
Phillip F Giannopoulos
Todd E Golde
P2860
P2888
P356
10.1186/1750-1326-7-1
P577
2012-01-05T00:00:00Z
P5875
P6179
1047300519