The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis. - Wikidata - wikimedia - TriplyDB

The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis.

The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis.

http://www.wikidata.org/entity/Q35754698

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Nutraceuticals in Parkinson's Disease The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration How to explain exercise-induced phenotype from molecular data: rethink and reconstruction based on AMPK and mTOR signaling.ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway.Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro.NDRG2 overexpression enhances glucose deprivation-mediated apoptosis in breast cancer cells via inhibition of the LKB1-AMPK pathway.Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells.JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction.The first European interdisciplinary ewing sarcoma research summit AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival.Koschei the immortal and anti-aging drugs Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population.Pharmacologic regulation of AMPK in breast cancer affects cytoskeletal properties involved with microtentacle formation and re-attachment Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK ERBB4 confers metastatic capacity in Ewing sarcoma Functional role of autophagy in gastric cancer.AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin.Targeting the LKB1 tumor suppressor.Curcumin targets the TFEB-lysosome pathway for induction of autophagy.The matricellular protein CYR61 promotes breast cancer lung metastasis by facilitating tumor cell extravasation and suppressing anoikis.The multifaceted activities of AMPK in tumor progression--why the "one size fits all" definition does not fit at all?The double-edged sword of AMPK signaling in cancer and its therapeutic implications.Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects.LKB1 pro-oncogenic activity triggers cell survival in circulating tumor cells.Calcium-Oxidant Signaling Network Regulates AMP-activated Protein Kinase (AMPK) Activation upon Matrix Deprivation.Anoikis-resistant cholangiocarcinoma cells display aggressive characteristics and increase STAT3 activation.Gelatin promotes murine fibrosarcoma L929 cell detachment and protects the cells from TNFα-induced cytotoxicity.AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms.Mechanical stretch activates mammalian target of rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells.The ethanolic extract of bark from Salix aegyptiaca L. inhibits the metastatic potential and epithelial to mesenchymal transition of colon cancer cell lines.LKB1 promotes metabolic flexibility in response to energy stress.Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer.A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer.The dark face of AMPK as an essential tumor promoter.Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes.Tetraspanins stimulate protein synthesis in myeloma cell lines.Mutation of the salt bridge-forming residues in the ETV6-SAM domain interface blocks ETV6-NTRK3-induced cellular transformation.SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis.

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P2860

The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis.

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C Chow

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P2860

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

AMPK and PPARdelta agonists are exercise mimetics

Disruption of epithelial cell-matrix interactions induces apoptosis

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

Growing roles for the mTOR pathway

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation.

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.

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10.1038/CDD.2011.119

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