Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers. - Wikidata - wikimedia - TriplyDB

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

http://www.wikidata.org/entity/Q35808718

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C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase A beta version of life: p110β takes center stage miR-221 is required for endothelial tip cell behaviors during vascular development Phosphoinositides: tiny lipids with giant impact on cell regulation The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit Signaling by the phosphoinositide 3-kinase family in immune cells Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.Regulation of p110delta PI 3-kinase gene expression.Genome-scale transcriptional analysis reveals key genes associated with the development of type II diabetes in mice.Protein Kinases as Drug Development Targets for Heart Disease Therapy Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.Activity of any class IA PI3K isoform can sustain cell proliferation and survival.In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function Phosphatidylinositol 3-kinase: the oncoprotein.A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K Exploring the role of two interacting phosphoinositide 3-kinases of Haemonchus contortus.PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.Four microRNAs promote prostate cell proliferation with regulation of PTEN and its downstream signals in vitro Identification of mutations in distinct regions of p85 alpha in urothelial cancer.Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis Phosphoinositide 3-kinase signaling in retinal rod photoreceptors.Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns.Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α.p85β phosphoinositide 3-kinase subunit regulates tumor progression Gemfibrozil, a lipid-lowering drug, induces suppressor of cytokine signaling 3 in glial cells: implications for neurodegenerative disorders Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.The role of phosphoinositide 3-kinase subunits in chronic thyroiditis.Role of phosphoinositides at the neuronal synapse.Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy p110δ PI3 kinase pathway: emerging roles in cancer.

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P2860

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

http://www.wikidata.org/entity/Q35808718

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年论文

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name

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

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Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

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Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

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Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

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Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

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Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

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P1476

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

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P2093

Barbara Geering

http://www.w3.org/2001/XMLSchema#string

Bart Vanhaesebroeck

http://www.w3.org/2001/XMLSchema#string

Gemma Nock

http://www.w3.org/2001/XMLSchema#string

Pedro R Cutillas

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Severine I Gharbi

http://www.w3.org/2001/XMLSchema#string

P2860

A biosensor approach to probe the structure and function of the p85 alpha subunit of the phosphatidylinositol 3-kinase complex

P110delta, a novel phosphoinositide 3-kinase in leukocytes

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS

Signaling by distinct classes of phosphoinositide 3-kinases

Synthesis and function of 3-phosphorylated inositol lipids

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

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104

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17470792

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1876529

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