Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples.
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Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistanceEmerging mechanisms of fluoroquinolone resistanceRoles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strainsGenomic transcriptional response to loss of chromosomal supercoiling in Escherichia coliDirect Optofluidic Measurement of the Lipid Permeability of Fluoroquinolones.Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylate Kinase: From Hit to Lead GenerationIn vitro anti-Mycobacterium avium activities of quinolones: predicted active structures and mechanistic considerationsN-1-tert-butyl-substituted quinolones: in vitro anti-Mycobacterium avium activities and structure-activity relationship studiesTricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agentsDynamical Model of Drug Accumulation in Bacteria: Sensitivity Analysis and Experimentally Testable PredictionsChemical biology of tetracycline antibioticsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.Roles of the carboxy-terminal half of Pseudomonas aeruginosa major outer membrane protein OprF in cell shape, growth in low-osmolarity medium, and peptidoglycan associationDetermination by fluorimetric titration of the ionization constants of ciprofloxacin in solution and in the presence of liposomes.Characterization of tetracycline modifying enzymes using a sensitive in vivo reporter systemRole of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacinRole of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance.Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide.Efflux-mediated resistance to fluoroquinolones in gram-negative bacteriaGeneral platform for systematic quantitative evaluation of small-molecule permeability in bacteria.Are natural products still the best source for antibacterial discovery? The bacterial entry factor.Effect of probenecid on the distribution and elimination of ciprofloxacin in humans.Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra.Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux systemActive efflux as a mechanism of resistance to ciprofloxacin in Streptococcus pneumoniae.Gene regulation by tetracyclines. Constraints of resistance regulation in bacteria shape TetR for application in eukaryotes.Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays.AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity.Tetracycline/H+ antiport and Na+/H+ antiport catalyzed by the Bacillus subtilis TetA(L) transporter expressed in Escherichia coli.Use of steroids to monitor alterations in the outer membrane of Pseudomonas aeruginosaEffective monitoring of concentrations of ofloxacin in saliva of patients with chronic respiratory tract infectionsQuinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome.Translating slow-binding inhibition kinetics into cellular and in vivo effectsBacteria lacking a multidrug pump: a sensitive tool for drug discovery.Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump.Outer membrane permeability and antibiotic resistance.Iron blocks the accumulation and activity of tetracyclines in bacteria.Biosolid-borne tetracyclines and sulfonamides in plants.Tetracycline Antibiotics and Resistance.Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives.Pharmacological characterization of 7-(4-(Piperazin-1-yl)) ciprofloxacin derivatives: antibacterial activity, cellular accumulation, susceptibility to efflux transporters, and intracellular activity.
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P2860
Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Penetration of lipophilic agen ...... fluoroquinolones as examples.
@ast
Penetration of lipophilic agen ...... fluoroquinolones as examples.
@en
type
label
Penetration of lipophilic agen ...... fluoroquinolones as examples.
@ast
Penetration of lipophilic agen ...... fluoroquinolones as examples.
@en
prefLabel
Penetration of lipophilic agen ...... fluoroquinolones as examples.
@ast
Penetration of lipophilic agen ...... fluoroquinolones as examples.
@en
P2860
P356
P1476
Penetration of lipophilic agen ...... fluoroquinolones as examples.
@en
P2093
D G Thanassi
P2860
P304
P356
10.1128/AAC.37.7.1393
P407
P577
1993-07-01T00:00:00Z