Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model.
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Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics)Is tau ready for admission to the prion club?Tau fragmentation, aggregation and clearance: the dual role of lysosomal processingChronic Stress and Glucocorticoids: From Neuronal Plasticity to NeurodegenerationTau clearance mechanisms and their possible role in the pathogenesis of Alzheimer diseaseToxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.Folding of the Tau Protein on MicrotubulesThe release and trans-synaptic transmission of Tau via exosomesIntrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau FragmentationCytoskeletal pathologies of Alzheimer diseaseNucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constantsPreventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.Co-expression of truncated and full-length tau induces severe neurotoxicityExperimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's diseaseA multi-factor model for caspase degradome predictionHirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain.Roles of tau protein in health and disease.Human stem cell-derived neurons: a system to study human tau function and dysfunctionTauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options.Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L miceImplicating calpain in tau-mediated toxicity in vivo.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Oligomer formation of tau protein hyperphosphorylated in cells.Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles.Isolation and characterization of antibody fragments selective for toxic oligomeric tauEctosomes: a new mechanism for non-exosomal secretion of tau protein.Are tangles as toxic as they look?Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's diseaseSecondary nucleating sequences affect kinetics and thermodynamics of tau aggregation.Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses.The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome.Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies.Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation.Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomesRemodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model.APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease.Asparaginyl endopeptidase cleaves TDP-43 in brainTau-based treatment strategies in neurodegenerative diseasesTau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies
P2860
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P2860
Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Stepwise proteolysis liberates ...... tau in a neuronal cell model.
@ast
Stepwise proteolysis liberates ...... tau in a neuronal cell model.
@en
type
label
Stepwise proteolysis liberates ...... tau in a neuronal cell model.
@ast
Stepwise proteolysis liberates ...... tau in a neuronal cell model.
@en
prefLabel
Stepwise proteolysis liberates ...... tau in a neuronal cell model.
@ast
Stepwise proteolysis liberates ...... tau in a neuronal cell model.
@en
P2093
P2860
P356
P1476
Stepwise proteolysis liberates ...... tau in a neuronal cell model.
@en
P2093
P2860
P304
10252-10257
P356
10.1073/PNAS.0703676104
P407
P577
2007-05-29T00:00:00Z