Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
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The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their AlkalinizationThe inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatmentEpidermal growth factor receptor inhibition reduces angiogenesis via hypoxia-inducible factor-1α and Notch1 in head neck squamous cell carcinomaAutophagy and cancer therapy.RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells.Regulation of OSU-03012 toxicity by ER stress proteins and ER stress-inducing drugs.OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis.PDE5 inhibitors enhance celecoxib killing in multiple tumor types.Lapatinib and obatoclax kill breast cancer cells through reactive oxygen species-dependent endoplasmic reticulum stress.Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline.GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells.Nexavar/Stivarga and viagra interact to kill tumor cells.Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cellsMcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells.Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemiaObatoclax kills anaplastic thyroid cancer cells by inducing lysosome neutralization and necrosisRegulation of the autophagic bcl-2/beclin 1 interaction.Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy.Identification of breast cancer cell subtypes sensitive to ATG4B inhibition.Novel pharmacological modulators of autophagy and therapeutic prospects.Recent insights into cell death and autophagy.Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects.The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastomaObatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells.Obatoclax induces G1/G0-phase arrest via p38/p21(waf1/Cip1) signaling pathway in human esophageal cancer cells.Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications.BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells.Single-agent obatoclax (GX15-070) potently induces apoptosis and pro-survival autophagy in head and neck squamous cell carcinoma cells.MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells.Targeting Oncogene-Induced Autophagy: A New Approach in Cancer Therapy?Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1
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P2860
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
@ast
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
@en
type
label
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
@ast
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
@en
prefLabel
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
@ast
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
@en
P2093
P2860
P356
P1476
Obatoclax and lapatinib interact to induce toxic autophagy through NOXA.
@en
P2093
Hossein A Hamed
Nichola Cruickshanks
Paul B Fisher
Steven Grant
P2860
P304
P356
10.1124/MOL.111.076851
P50
P577
2012-01-04T00:00:00Z