Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons. - Wikidata - wikimedia - TriplyDB

Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons.

Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons.

http://www.wikidata.org/entity/Q35855944

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Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin Short mitochondrial ARF triggers Parkin/PINK1-dependent mitophagy Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons Hexokinase activity is required for recruitment of parkin to depolarized mitochondria Alterations in Mitochondrial Quality Control in Alzheimer's Disease Induced pluripotent stem cells in Parkinson's disease: scientific and clinical challenges Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy Parkin structure and function The pathways of mitophagy for quality control and clearance of mitochondria After the banquet: mitochondrial biogenesis, mitophagy, and cell survival Advances in Stem Cell Research- A Ray of Hope in Better Diagnosis and Prognosis in Neurodegenerative Diseases Autophagosome dynamics in neurodegeneration at a glance Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy Mitophagy mechanisms and role in human diseases Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control Beyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial health Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathway Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy Neuronal Mitophagy in Neurodegenerative Diseases Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease.PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease.Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.Efavirenz induces neuronal autophagy and mitochondrial alterations.Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo.PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria Mitochondrial DNA: impacting central and peripheral nervous systems.A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis Regulation of mitochondrial transport in neurons.The Organization of Mitochondrial Quality Control and Life Cycle in the Nervous System In Vivo in the Absence of PINK1.Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease.(Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation

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P2860

Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons.

http://www.wikidata.org/entity/Q35855944

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Spatial parkin translocation a ...... hagy in live cortical neurons.

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Spatial parkin translocation a ...... hagy in live cortical neurons.

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type

label

Spatial parkin translocation a ...... hagy in live cortical neurons.

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Spatial parkin translocation a ...... hagy in live cortical neurons.

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prefLabel

Spatial parkin translocation a ...... hagy in live cortical neurons.

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Spatial parkin translocation a ...... hagy in live cortical neurons.

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J.CUB.2012.02.005

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Current Biology

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Spatial parkin translocation a ...... hagy in live cortical neurons.

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Anthony Simone

http://www.w3.org/2001/XMLSchema#string

Hesham Mostafa Zakaria

http://www.w3.org/2001/XMLSchema#string

Qian Cai

http://www.w3.org/2001/XMLSchema#string

Zu-Hang Sheng

http://www.w3.org/2001/XMLSchema#string

P2860

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells

Parkin interacts with Ambra1 to induce mitophagy

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons

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