Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.
about
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediatesStudies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1Okazaki fragment maturation: nucleases take centre stageRational design of human DNA ligase inhibitors that target cellular DNA replication and repairMammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrityWuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer.Hypomorphic PCNA mutation underlies a human DNA repair disorder.Processing of lagging-strand intermediates in vitro by herpes simplex virus type 1 DNA polymeraseMethylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA bindingThe FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.Kinetics of endogenous mouse FEN1 in base excision repair.Functional regulation of FEN1 nuclease and its link to cancerA five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis.Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancerA fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cellsOkazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex.Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system.Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis.Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria.PCNA stimulates catalysis by structure-specific nucleases using two distinct mechanisms: substrate targeting and catalytic step.Mutation of DNA Polymerase β R137Q Results in Retarded Embryo Development Due to Impaired DNA Base Excision Repair in MiceThe wonders of flap endonucleases: structure, function, mechanism and regulation.Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repairComprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathwaysThe FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation.Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression.Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.Dna2 on the road to Okazaki fragment processing and genome stability in eukaryotes.The role of the DNA sliding clamp in Okazaki fragment maturation in archaea and eukaryotes.The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.Mapping the FEN1 interaction domain with hTERT.Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substratesTriptolide-Assisted Phosphorylation of p53 Suppresses Inflammation-Induced NF-κB Survival Pathways in Cancer Cells.Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus.SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress
P2860
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P2860
Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Disruption of the FEN-1/PCNA i ...... and newborn lethality in mice.
@ast
Disruption of the FEN-1/PCNA i ...... and newborn lethality in mice.
@en
type
label
Disruption of the FEN-1/PCNA i ...... and newborn lethality in mice.
@ast
Disruption of the FEN-1/PCNA i ...... and newborn lethality in mice.
@en
prefLabel
Disruption of the FEN-1/PCNA i ...... and newborn lethality in mice.
@ast
Disruption of the FEN-1/PCNA i ...... and newborn lethality in mice.
@en
P2093
P2860
P356
P1476
Disruption of the FEN-1/PCNA i ...... and newborn lethality in mice.
@en
P2093
Binghui Shen
Huifang Dai
Junzhuan Qiu
P2860
P304
P356
10.1128/MCB.01652-06
P407
P577
2007-02-05T00:00:00Z