The wonders of flap endonucleases: structure, function, mechanism and regulation.
about
A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clampCellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active siteThe tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progressionRECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.Flap endonuclease activity of gene 6 exonuclease of bacteriophage T7.Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1.The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.DNA Repair Endonucleases: Physiological Roles and Potential as Drug Targets.Risky repair: DNA-protein crosslinks formed by mitochondrial base excision DNA repair enzymes acting on free radical lesions.DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction.Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substratesCrystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing.Observation of unpaired substrate DNA in the flap endonuclease-1 active site.A Flap Endonuclease (TcFEN1) Is Involved in Trypanosoma cruzi Cell Proliferation, DNA Repair, and Parasite Survival.Roles for the Rad27 Flap Endonuclease in Mitochondrial Mutagenesis and Double-Strand Break Repair in Saccharomyces cerevisiae.Direct Visualization of RNA-DNA Primer Removal from Okazaki Fragments Provides Support for Flap Cleavage and Exonucleolytic Pathways in Eukaryotic Cells.The GAN Exonuclease or the Flap Endonuclease Fen1 and RNase HII Are Necessary for Viability of Thermococcus kodakarensis.The DNA Repair Repertoire of Mycobacterium smegmatis FenA Includes the Incision of DNA 5' Flaps and the Removal of 5' Adenylylated Products of Aborted Nick Ligation.Positioning the 5'-flap junction in the active site controls the rate of flap endonuclease-1-catalyzed DNA cleavage.Crystal structure and mutational analysis of Mycobacterium smegmatis FenA highlight active site amino acids and three metal ions essential for flap endonuclease and 5' exonuclease activities.Investigation of sliding DNA clamp dynamics by single-molecule fluorescence, mass spectrometry and structure-based modeling.
P2860
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P2860
The wonders of flap endonucleases: structure, function, mechanism and regulation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
The wonders of flap endonucleases: structure, function, mechanism and regulation.
@en
The wonders of flap endonucleases: structure, function, mechanism and regulation.
@nl
type
label
The wonders of flap endonucleases: structure, function, mechanism and regulation.
@en
The wonders of flap endonucleases: structure, function, mechanism and regulation.
@nl
prefLabel
The wonders of flap endonucleases: structure, function, mechanism and regulation.
@en
The wonders of flap endonucleases: structure, function, mechanism and regulation.
@nl
P2093
P2860
P1476
The wonders of flap endonucleases: structure, function, mechanism and regulation
@en
P2093
Binghui Shen
Jane Grasby
John M Atack
Scott Classen
Susan Tsutakawa
P2860
P304
P356
10.1007/978-94-007-4572-8_16
P577
2012-01-01T00:00:00Z