Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization - Wikidata - wikimedia - TriplyDB

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

http://www.wikidata.org/entity/Q35857019

about

Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer Regulation of Bim in Health and Disease The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins GSK-3 as potential target for therapeutic intervention in cancer Signaling cross-talk in the resistance to HER family receptor targeted therapy SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties.The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions Roles of caveolin-1 on anoikis resistance in non small cell lung cancer Cell biology. Metabolic control of cell death Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent Modulation of GSK-3β activity in Venezuelan equine encephalitis virus infection SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer.Regulation of protein stability by GSK3 mediated phosphorylation.GSK-3: Functional Insights from Cell Biology and Animal Models.GSK3β controls epithelial-mesenchymal transition and tumor metastasis by CHIP-mediated degradation of Slug Glycogen synthase kinase-3 inhibition disrupts nuclear factor-kappaB activity in pancreatic cancer, but fails to sensitize to gemcitabine chemotherapy beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor.On to the road to degradation: atherosclerosis and the proteasome High fluence low-power laser irradiation induces apoptosis via inactivation of Akt/GSK3β signaling pathway.Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma.Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis Mcl-1 ubiquitination: unique regulation of an essential survival protein.Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression Getting Syk: spleen tyrosine kinase as a therapeutic target.Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism PINK1 triggers autocatalytic activation of Parkin to specify cell fate decisions SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination.Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.

P2860

Q23923209-9346F143-73BD-481D-88F5-59AF80E47F7D Q24295177-B78A9D4A-3939-4299-8A3C-DB1720434EE0 Q24301935-4D69A1CD-0798-4E04-A146-CF24B770B371 Q24313648-2B142673-3D6D-477A-A02A-57D3F45B5B4D Q24603213-73BCA0D5-D6C4-480F-8883-9B66F0F31935 Q24643422-50EE79BC-210E-4C30-AEC9-022789961DFF Q24648025-B2C6145C-E89F-4326-BFB3-86937AE63708 Q26781203-7579E723-CE45-44E4-A301-346394BD9823 Q26782159-DCF16B76-9700-4770-BE76-E3F6E8850CAA Q26825421-5C2A4C03-E154-484B-8261-1CF35AEE5222 Q27013811-8B526946-3B2B-4B4A-8551-AC07D70F5EA2 Q27027778-13A040C5-0046-40E9-A8E7-C8D9A1E2DD2F Q27341897-A60E1844-D9B5-4BFE-9A10-9E888CD0DCFA Q28067104-0DD69868-45DC-436C-B597-D7B799BA23E5 Q28389527-CB6940E0-23DA-474E-8A16-899007388C3B Q28397089-6C53F992-2E5C-4748-84C6-6EC0F398E310 Q28484291-25A8532A-8F9B-442C-8267-2022DB7470A8 Q28484382-D5ED81FB-FF3E-4A17-8676-7D1E52FCEB4A Q28730748-2AEDAC10-BD11-47AD-99B7-4386404B997F Q28818138-DC97A315-7920-4CAD-9E7C-CD9A082A2F73 Q30405442-75052E97-DF53-4EBC-AD53-A6B2F1EC8610 Q30437017-86F0FB1A-6516-49BB-94F5-2E3108024DB1 Q30472813-36CC18DD-468B-4FDE-AF08-A8AFA7D6AFFC Q30583575-FBBA55E8-3D1F-4F8A-B149-AC13BAE6044D Q33437264-E81258BE-6F96-47FD-B431-1CCD4F952845 Q33530099-0246BC88-2FF3-45F6-82C9-2664FBD0C591 Q33554513-36B427F5-0065-4F19-AD10-CC527DADD712 Q33648923-651C3D71-7F67-4B37-B93D-0E2A3A598573 Q33839850-F7FC679E-0845-4EDA-9726-17C400687631 Q33851111-60722A7A-8F6C-4463-BD25-25AC4C41C267 Q33883844-EE37AA90-05C0-4FCA-AE11-AE709F816972 Q33975692-FE0D3926-23D7-469B-96DD-6F928D030F90 Q33989964-9B868E39-C6A0-411C-8D33-28D6859B2457 Q33993750-C9EB10D2-763E-41AE-999C-AAC92F5F9EB6 Q34070349-F1D77F90-512D-42BF-837C-2FB0FA616DBE Q34079481-741BE6C3-24E5-4D9F-8AB4-F61486E4CDC3 Q34084176-59E6D342-58E6-4D6D-85D0-5E8E3CF90319 Q34100910-CE0DD8B4-1042-4C58-BE6A-9C44A7CE8B9E Q34135542-7B9B5A35-F8F8-44DA-99AB-BB4C036FD13C Q34166041-CC49C837-6EE1-451D-BA06-5068738D7426

P2860

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

http://www.wikidata.org/entity/Q35857019

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

2007年论文

@zh

2007年论文

@zh-cn

name

Degradation of Mcl-1 by beta-T ...... ression and chemosensitization

@ast

Degradation of Mcl-1 by beta-T ...... ression and chemosensitization

@en

type

label

Degradation of Mcl-1 by beta-T ...... ression and chemosensitization

@ast

Degradation of Mcl-1 by beta-T ...... ression and chemosensitization

@en

prefLabel

Degradation of Mcl-1 by beta-T ...... ression and chemosensitization

@ast

Degradation of Mcl-1 by beta-T ...... ression and chemosensitization

@en

P1433

Q35857019-594D269C-5AEF-4716-8559-0C985E3AABAA

P1476

Q35857019-E40BB748-7252-4216-B5C9-002F818CBC87

P2093

Q35857019-347A9B9A-EE3F-487A-BAE1-06051352EDFC

Q35857019-403D74E1-06D2-4F42-959A-9B8EB3ECDF65

Q35857019-50316E03-FBFA-40F7-A163-9E4E7E6BAF55

Q35857019-765F12E7-6F92-4E67-A7E5-0B13A4067F23

Q35857019-7CA7FC2A-C841-4597-B6FA-E047593E8184

Q35857019-81AFAB90-50C6-4D29-9E29-FF910D5C2C5A

Q35857019-826E7896-2329-427D-A77C-440BC0E27639

Q35857019-8DA7F1E7-1CD7-45E5-B5CD-C7B9A499708E

Q35857019-A374B618-ED8B-40AB-94DC-E514AAA49848

Q35857019-EE5022A2-A98A-4AB3-924A-18DDEFE51EFE

P2860

Q35857019-0061D2CB-5887-41D3-8443-34180DA7434E

Q35857019-017BDC5F-633B-4145-BD1D-CF1BD2CFE22E

Q35857019-08E5E232-F2B3-4C94-836D-2BB4812DF4DC

Q35857019-0CE7A76D-6A73-4949-9255-0A528C23AE9D

Q35857019-1633B4A0-C52B-4975-9D71-A1671495716A

Q35857019-2A6482C2-B188-4CD9-89A0-75B814547A95

Q35857019-2D3C0730-BB0B-4BD1-9211-225A3FF9FF67

Q35857019-32FC098F-0B16-47B3-9DBF-7E49E1236267

Q35857019-3D1B5BAA-4D82-442B-A234-A04CD3C50001

Q35857019-43881957-7F32-4E74-9C34-15F38E83CB35

P304

Q35857019-9244E26F-D37B-4C91-AC82-DA88D3AC6502

P31

Q35857019-66692C89-2DE2-4DD7-8E53-C9176A9DF63C

P356

Q35857019-4B57C8BF-6CED-4CF3-AFDE-237D8D910785

P407

Q35857019-9B24ED53-1C37-4366-9D30-E8B7957EC256

P433

Q35857019-67B45E52-FC76-4676-80F2-442A0C93D527

P478

Q35857019-C47DFAF7-169C-4E36-931A-41F78E32447A

P577

Q35857019-5712D752-A1DF-4587-9CE2-DC0E2D744272

P5875

Q35857019-218C1BF1-8F9C-411B-80C4-F6AABBE8A986

P698

Q35857019-46F2E888-5A50-4850-9B19-F51D4A35FC8B

P932

Q35857019-44D9656E-1B37-4FEE-95A7-E449EA37A53F

P356

P1433

Molecular and Cellular Biology

P1476

Degradation of Mcl-1 by beta-T ...... ression and chemosensitization

@en

P2093

Chun-Te Chen

http://www.w3.org/2001/XMLSchema#string

Dung-Fang Lee

http://www.w3.org/2001/XMLSchema#string

Jaw-Ching Liu

http://www.w3.org/2001/XMLSchema#string

Jung-Mao Hsu

http://www.w3.org/2001/XMLSchema#string

Long-Yuan Li

http://www.w3.org/2001/XMLSchema#string

Mien-Chie Hung

http://www.w3.org/2001/XMLSchema#string

Qing Zhong

http://www.w3.org/2001/XMLSchema#string

Qingqing Ding

http://www.w3.org/2001/XMLSchema#string

Weiya Xia

http://www.w3.org/2001/XMLSchema#string

Xianghuo He

http://www.w3.org/2001/XMLSchema#string

P2860

The Hallmarks of Cancer

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

GSK-3: tricks of the trade for a multi-tasking kinase

Death and anti-death: tumour resistance to apoptosis

beta-catenin is a target for the ubiquitin-proteasome pathway

P304

4006-4017

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.00620-06

http://www.w3.org/2001/XMLSchema#string

P407

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

27

http://www.w3.org/2001/XMLSchema#string

P577

2007-03-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6420727

http://www.w3.org/2001/XMLSchema#string

P698

17387146

http://www.w3.org/2001/XMLSchema#string

P932

1900029

http://www.w3.org/2001/XMLSchema#string