An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.
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The Significance of Ras Activity in Pancreatic Cancer InitiationRoles of Commensal Microbiota in Pancreas Homeostasis and Pancreatic PathologiesInherited pancreatic cancer syndromesHuman correlates of provocative questions in pancreatic pathologyDynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironmentCaught in the cross fire: p53 in inflammation.Application of glycoscience to the early detection of pancreatic cancerUtilizing past and present mouse systems to engineer more relevant pancreatic cancer modelsAnimal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitisInterleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistanceThe anti-tumor effect of HDAC inhibition in a human pancreas cancer model is significantly improved by the simultaneous inhibition of cyclooxygenase 2Obesity and cancer pathogenesis.Context-Dependent Effects of Amplified MAPK Signaling during Lung Adenocarcinoma Initiation and Progression.Inflammation to cancer: The molecular biology in the pancreas (Review).Targeting reactive nitrogen species suppresses hereditary pancreatic cancer.Advances in acute and chronic pancreatitis: from development to inflammation and repair.The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic TumorigenesisPancreatic cancer, inflammation, and microbiome.Pancreatic cancer and its stroma: a conspiracy theoryPromotion of lung tumor growth by interleukin-17Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions.Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110αDiscovering the route from inflammation to pancreatic cancer.Pancreatitis-diabetes-pancreatic cancer: summary of an NIDDK-NCI workshop.Kras as a key oncogene and therapeutic target in pancreatic cancerProstaglandin E2 reverses curcumin-induced inhibition of survival signal pathways in human colorectal carcinoma (HCT-15) cell linesImpact of diabetes type II and chronic inflammation on pancreatic cancer.Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions.Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia.TRPV1 potentiates TGFβ-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop.Regeneration and repair of the exocrine pancreas.Persistent salmonellosis causes pancreatitis in a murine model of infectionDeregulation of the MiR-193b-KRAS Axis Contributes to Impaired Cell Growth in Pancreatic CancerMitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashionThe acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinomaNKX2-1-mediated p53 expression modulates lung adenocarcinoma progression via modulating IKKβ/NF-κB activation.Animal Models of Gastrointestinal and Liver Diseases. The difficulty of animal modeling of pancreatic cancer for preclinical evaluation of therapeutics.CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma.K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions.Modification of the Tumor Microenvironment in KRAS or c-MYC-Induced Ovarian Cancer-Associated Peritonitis
P2860
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P2860
An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
An NF-κB pathway-mediated posi ...... o pathological levels in mice.
@ast
An NF-κB pathway-mediated posi ...... o pathological levels in mice.
@en
type
label
An NF-κB pathway-mediated posi ...... o pathological levels in mice.
@ast
An NF-κB pathway-mediated posi ...... o pathological levels in mice.
@en
prefLabel
An NF-κB pathway-mediated posi ...... o pathological levels in mice.
@ast
An NF-κB pathway-mediated posi ...... o pathological levels in mice.
@en
P2093
P2860
P356
P1476
An NF-κB pathway-mediated posi ...... to pathological levels in mice
@en
P2093
Craig D Logsdon
Defeng Deng
Haojie Huang
Huamin Wang
Sebastian Gaiser
Zobeida Cruz-Monserrate
P2860
P304
P356
10.1172/JCI59743
P407
P577
2012-03-12T00:00:00Z