Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. - Wikidata - wikimedia - TriplyDB

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity.

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity.

http://www.wikidata.org/entity/Q35865833

about

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response Highlight: BRCA1 and BRCA2 proteins in breast cancer The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex Distinct functions of BRCA1 and BRCA2 in double-strand break repair The Icelandic founder mutation BRCA2 999del5: analysis of expression A guide for functional analysis of BRCA1 variants of uncertain significance RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity.Trial Watch: Proteasomal inhibitors for anticancer therapy Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins Dysregulation of ubiquitin ligases in cancer Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1 NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export Redistribution of BRCA1 among four different protein complexes following replication blockage Identification of residues required for the interaction of BARD1 with BRCA1 BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein Is there more to BARD1 than BRCA1?BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses Minding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forks BRCA1 and Oxidative Stress BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation The relationship of recombination rate, genome structure, and patterns of molecular evolution across angiosperms Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks

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P2860

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity.

http://www.wikidata.org/entity/Q35865833

description

2001 nî lūn-bûn

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2001年論文

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2001年论文

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Cancer-predisposing mutations ...... om radiation hypersensitivity.

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Cancer-predisposing mutations ...... om radiation hypersensitivity.

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Cancer-predisposing mutations ...... om radiation hypersensitivity.

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Cancer-predisposing mutations ...... om radiation hypersensitivity.

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Cancer-predisposing mutations ...... om radiation hypersensitivity.

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Cancer-predisposing mutations ...... om radiation hypersensitivity.

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Proceedings of the National Academy of Sciences of the United States of America

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Cancer-predisposing mutations ...... om radiation hypersensitivity.

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P2093

C A Joazeiro

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D Hemmati

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H Ruffner

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I M Verma

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T Hunter

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P2860

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

Genetic analysis of BRCA1 function in a defined tumor cell line

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