Genetic analysis of BRCA1 function in a defined tumor cell line
about
P1343
BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations.Multifunctional transcription factor TFII-I is an activator of BRCA1 functionLocalization of BRCA1 protein in breast cancer tissue and cell lines with mutationsMERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaksCCDC98 targets BRCA1 to DNA damage sitesBRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localizationFunctional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stressSTRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repairBASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structuresThe BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutationsDeficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joiningThe ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair responseAssociation of BRCA1 with the inactive X chromosome and XIST RNARole of BRCA gene dysfunction in breast and ovarian cancer predisposition.BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionA guide for functional analysis of BRCA1 variants of uncertain significanceStructural consequences of a cancer-causing BRCA1-BRCT missense mutationPathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approachBeyond DNA: An Integrated and Functional Approach for Classifying Germline Variants in Breast Cancer GenesAn hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modificationStructure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancerBRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damageMiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibitionMinding the gap: the underground functions of BRCA1 and BRCA2 at stalled replication forksEfficacy of neoadjuvant Cisplatin in triple-negative breast cancerIdentification of a Small Molecule Inhibitor of RAD52 by Structure-Based SelectionLoss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instabilityBARD1 participates with BRCA1 in homology-directed repair of chromosome breaksIn search of the tumour-suppressor functions of BRCA1 and BRCA2Gene Expression Variations in Microsatellite Stable and Unstable Colon Cancer Cells53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaksA functional comparison of BRCA1 C-terminal domains in transcription activation and chromatin remodeling.Characterization of a novel trans-activation domain of BRCA1 that functions in concert with the BRCA1 C-terminal (BRCT) domain.BRCA1 modulates ionizing radiation-induced nuclear focus formation by the replication protein A p34 subunit.Assessment of human Nter and Cter BRCA1 mutations using growth and localization assays in yeast.Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication.Targeted comparative RNA interference analysis reveals differential requirement of genes essential for cell proliferationRole of BRCA1 in brain development.
P2860
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P2860
Genetic analysis of BRCA1 function in a defined tumor cell line
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Genetic analysis of BRCA1 function in a defined tumor cell line
@ast
Genetic analysis of BRCA1 function in a defined tumor cell line
@en
Genetic analysis of BRCA1 function in a defined tumor cell line
@nl
type
label
Genetic analysis of BRCA1 function in a defined tumor cell line
@ast
Genetic analysis of BRCA1 function in a defined tumor cell line
@en
Genetic analysis of BRCA1 function in a defined tumor cell line
@nl
prefLabel
Genetic analysis of BRCA1 function in a defined tumor cell line
@ast
Genetic analysis of BRCA1 function in a defined tumor cell line
@en
Genetic analysis of BRCA1 function in a defined tumor cell line
@nl
P2093
P3181
P1433
P1476
Genetic analysis of BRCA1 function in a defined tumor cell line
@en
P2093
D M Livingston
K Vlasakova
M Socolovsky
P304
P3181
P356
10.1016/S1097-2765(00)80238-5
P407
P4510
P577
1999-12-01T00:00:00Z