Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.
about
Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptorRoles of Zinc Signaling in the Immune SystemExpression of the Bcl-2 family member A1 is developmentally regulated in T cellsVhlh gene deletion induces Hif-1-mediated cell death in thymocytesc-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xLBoth leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199.Itk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells.BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte developmentMcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2.Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor.Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selectionBcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic miceProtein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivoLineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells.Ligation of CD8 leads to apoptosis of thymocytes that have not undergone positive selection.Apoptosis and autophagy in the regulation of T lymphocyte functionDying to protect: cell death and the control of T-cell homeostasis.Fine-tuning of T-cell development by the CD3γ di-leucine-based TCR-sorting motif.Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules.The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development.Detection of thymocytes apoptosis in mice induced by organochlorine pesticides methoxychlor.TCR v(beta) repertoire restriction and lack of CDR3 conservation implicate TCR-superantigen interactions in promoting the clonal evolution of murine thymic lymphomas.Bcl-2 maturation pattern in T-cells distinguishes thymic neoplasm/hyperplasia, T-lymphoblastic lymphoma, and reactive lymph nodes.Overexpression of the antiapoptotic protein A1 promotes the survival of double positive thymocytes awaiting positive selection.DN2 Thymocytes Activate a Specific Robust DNA Damage Response to Ionizing Radiation-Induced DNA Double-Strand Breaks.
P2860
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P2860
Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Bcl-2 expression during T-cell ...... differentiation and survival.
@ast
Bcl-2 expression during T-cell ...... differentiation and survival.
@en
type
label
Bcl-2 expression during T-cell ...... differentiation and survival.
@ast
Bcl-2 expression during T-cell ...... differentiation and survival.
@en
prefLabel
Bcl-2 expression during T-cell ...... differentiation and survival.
@ast
Bcl-2 expression during T-cell ...... differentiation and survival.
@en
P2093
P2860
P356
P1476
Bcl-2 expression during T-cell ...... differentiation and survival.
@en
P2093
J Gratiot-Deans
P2860
P304
10685-10689
P356
10.1073/PNAS.91.22.10685
P407
P577
1994-10-01T00:00:00Z