Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells.
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Death by a B cell superantigen: In vivo VH-targeted apoptotic supraclonal B cell deletion by a Staphylococcal ToxinB cell receptor editing in tolerance and autoimmunityA gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivoDecoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivoApotosis of mature B cells.Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.Receptor selection in B and T lymphocytes.Revising B cell receptorsmiRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.Receptor revision and systemic lupus.Dysregulation of apoptosis and a novel mechanism of defective apoptotic signal transduction in human B-cell neoplasms.Rescue of self-reactive B cells by provision of T cell help in vivo.Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.A mouse variable gene fragment binds to DNA independently of the BCR context: a possible role for immature B-cell repertoire establishment.Changes in gene expression profiles in developing B cells of murine bone marrowEnforced expression of the apoptosis inhibitor Bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanismCharacterization of antigen-specific B cells using nominal antigen-coated flow-beads.The control of apoptosis in lymphocyte selection.Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls.The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production.Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escapeB-cell antigen-receptor signalling in lymphocyte development.Molecular mechanisms guiding late stages of B-cell development.Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection.A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion.Natural regulatory T cells and self-tolerance.Endogenous antigen tunes the responsiveness of naive B cells but not T cellsLoss of the proapoptotic protein, Bim, breaks B cell anergyB cell reductive therapy in the treatment of autoimmune diseases: a focus on monoclonal antibody treatment of rheumatoid arthritis.Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouseHuman autoantibody silencing by immunoglobulin light chainsAn immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune systemEfficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenesA role for interferon regulatory factor 4 in receptor editing.Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivityRapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo.Multiple paths to loss of anergy and gain of autoimmunity.What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain.Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAsBasal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.
P2860
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P2860
Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Enforced Bcl-2 expression inhi ...... utoreactive, immature B cells.
@ast
Enforced Bcl-2 expression inhi ...... utoreactive, immature B cells.
@en
type
label
Enforced Bcl-2 expression inhi ...... utoreactive, immature B cells.
@ast
Enforced Bcl-2 expression inhi ...... utoreactive, immature B cells.
@en
prefLabel
Enforced Bcl-2 expression inhi ...... utoreactive, immature B cells.
@ast
Enforced Bcl-2 expression inhi ...... utoreactive, immature B cells.
@en
P2093
P2860
P356
P1476
Enforced Bcl-2 expression inhi ...... utoreactive, immature B cells.
@en
P2093
A W Harris
G Hammerling
S Korsmeyer
P2860
P304
P356
10.1084/JEM.186.9.1513
P407
P577
1997-11-01T00:00:00Z