Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199
about
Mitochondria, cholesterol and cancer cell metabolismMitochondrial apoptosis and BH3 mimeticsHematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell CistromeMitochondrial Profiling of Acute Myeloid Leukemia in the Assessment of Response to Apoptosis Modulating DrugsVenetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia.Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia.Akacid medical formulation induces apoptosis in myeloid and lymphatic leukemic cell lines in vitro and in vivoGenomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis.Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactionsMLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemiaBH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics.Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family membersDefining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines.Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype.Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemiaMLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylationMcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells.Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia.Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia.Mitochondria-Judges and Executioners of Cell Death Sentences.Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.Targeting childhood, adolescent and young adult non-Hodgkin lymphoma: therapeutic horizons.Venetoclax: First Global Approval.Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia.Restraining FOXO3-dependent transcriptional BMF activation underpins tumour growth and metastasis of E-cadherin-negative breast cancerPIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax.Combined venetoclax and alvocidib in acute myeloid leukemia.Why do BCL-2 inhibitors work and where should we use them in the clinic?T-PLL: another check on the venetoclax list?Synergy of BCL2 and histone deacetylase inhibition against leukemic cells from cutaneous T-cell lymphoma patients.Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.Acute myeloid/T-lymphoblastic leukaemia (AMTL): a distinct category of acute leukaemias with common pathogenesis in need of improved therapy.Pathways and mechanisms of venetoclax resistance.LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.Role of apoptotic markers in paediatric acute lymphoblastic leukaemia.
P2860
Q26741708-02E8E285-CC81-4127-88C3-274C0A09A228Q28069552-B8B112BD-606A-4161-960B-69AD42DBEAD6Q28263427-20A34017-60D1-4104-A247-B4BA29341C42Q28548058-3F4E6596-0F95-49B1-B3AB-CB0C19821D8DQ33433407-4C5A806E-C116-4645-8F4A-E00DC0A4DD40Q33702409-36319406-4EF5-474A-9DEE-1A45E8EC4DCFQ35101648-8DE85A7D-ACAA-4773-86F2-35A5D1789A51Q36154689-FB254DE9-4275-44C3-9025-C812733CD35CQ36284637-BD1CFD76-6987-4910-9CF8-975B99AAA739Q36314597-2685D608-8022-4D0F-AF1A-3758209F95D1Q36426910-09A50C32-DE4D-42D1-8105-14B1EE0D44A5Q36436934-17D861C7-7D09-4F66-B8DC-B568BC2B7C23Q36468244-4F030820-1DF2-470F-98DF-9BFD888CC1E3Q36601134-312BA24B-C4FB-4BEA-979B-4B5E451003F6Q36998291-BBA5635E-1FAB-474F-8CC0-926BA2D7AB13Q37026039-8340BE22-0091-4668-B9BC-36A5E77491E1Q37140487-09B2F974-FB95-46A2-ACA7-A90110F18296Q37676956-617D631F-4F47-464C-92EE-022796A59A45Q37706871-E9F74871-ED04-477F-9959-023C2AF79626Q38602949-B44C042E-C1AF-4386-926C-81C1E2A98AF9Q38712212-F30DFA1A-F151-471B-AFF2-E73CB5C1C6C2Q38722012-9250BDD0-38D7-4043-8BA7-EA008D2B971AQ38760561-FBBB1E06-9B11-49AD-AEEE-F1F2EAA0ED7BQ38782374-B51E8C0C-2D4C-4807-8D73-AF57B037F98EQ38790957-6D3F7849-DBB7-4ED7-A9BD-50893189F94BQ38853500-9BE0E74C-95A6-42F9-AACE-2DD739D68A78Q38999126-2EC2836F-7D27-4C16-A4E9-16FDAA75A9FCQ41517649-CE0160AC-3578-4DCC-9DAC-47B815A14767Q42283077-DD0237A8-4FD5-4EB0-8873-4DCFA6E9F3B8Q46370948-FFED86CC-9EB8-4E07-A02F-B66052E4B34DQ47105216-EF77C988-3179-427B-A22E-198A974C86DFQ47159040-AD14B4EC-6068-49DD-AAE3-CFFBE35256FEQ47235165-AF1B9513-ABFA-4907-A90E-67D029034C57Q47567993-F8616946-4F02-4C51-8A07-531F8841868CQ48127990-65E81785-C92F-4A9B-AE6C-47032B6E50D0Q50020680-B0535A7D-B630-41B2-AC27-2A36991CF522Q51160342-24AB161A-D9A6-449E-8434-041D67F47C02Q52822414-08E3BF63-1F61-463B-81D9-B197E2F481AEQ55516451-454D4802-A367-4E8B-BDA9-EFD1B85A0731Q55606159-2C5780E0-1EB3-49E7-81A7-F9430265E9E1
P2860
Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Maturation stage of T-cell acu ...... nce and sensitivity to ABT-199
@ast
Maturation stage of T-cell acu ...... nce and sensitivity to ABT-199
@en
Maturation stage of T-cell acu ...... nce and sensitivity to ABT-199
@nl
type
label
Maturation stage of T-cell acu ...... nce and sensitivity to ABT-199
@ast
Maturation stage of T-cell acu ...... nce and sensitivity to ABT-199
@en
Maturation stage of T-cell acu ...... nce and sensitivity to ABT-199
@nl
prefLabel
Maturation stage of T-cell acu ...... nce and sensitivity to ABT-199
@ast
Maturation stage of T-cell acu ...... nce and sensitivity to ABT-199
@en
Maturation stage of T-cell acu ...... nce and sensitivity to ABT-199
@nl
P2093
P2860
P1433
P1476
Maturation stage of T-cell acu ...... nce and sensitivity to ABT-199
@en
P2093
Alejandro Gutierrez
Anthony Letai
Brent Wood
Daniel J DeAngelo
Justine E Roderick
Lewis B Silverman
Marian Harris
Michelle A Kelliher
Mignon L Loh
Richard Stone
P2860
P304
P356
10.1158/2159-8290.CD-14-0353
P577
2014-07-03T00:00:00Z