Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
about
Emerging Targets of Diuretic Therapy.Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors.The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapyFunctional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brainWNK signalling pathways in blood pressure regulationLeveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition.Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule.Gender difference in kidney electrolyte transport. I. Role of AT1a receptor in thiazide-sensitive Na+-Cl- cotransporter activity and expression in male and female mice.Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains.
P2860
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P2860
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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2015年论文
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2015年论文
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name
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
@ast
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
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type
label
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
@ast
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
@en
prefLabel
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
@ast
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
@en
P2093
P2860
P356
P1476
Critical role of the SPAK protein kinase CCT domain in controlling blood pressure
@en
P2093
Dario R Alessi
Kevin M O'Shaughnessy
Thomas Macartney
P2860
P304
P356
10.1093/HMG/DDV185
P577
2015-05-20T00:00:00Z