The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.
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PML nuclear bodiesThe growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylasesEvidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infectionsMediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expressionStructural and functional heterogeneity of nuclear bodiesThe promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoterViral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruptionProteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression.Epstein-barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodiesAbility of the human cytomegalovirus IE1 protein to modulate sumoylation of PML correlates with its functional activities in transcriptional regulation and infectivity in cultured fibroblast cellsAnalysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infectionIntrinsic host restriction factors of human cytomegalovirus replication and mechanisms of viral escapeThe DNA damage response induced by infection with human cytomegalovirus and other virusesCyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinasesKaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivationGenome-wide screen of three herpesviruses for protein subcellular localization and alteration of PML nuclear bodiesA human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication.A role for cytoplasmic PML in cellular resistance to viral infectionMurine gammaherpesvirus 68 ORF75c contains ubiquitin E3 ligase activity and requires PML SUMOylation but not other known cellular PML regulators, CK2 and E6AP, to mediate PML degradationThe carboxy terminal region of the human cytomegalovirus immediate early 1 (IE1) protein disrupts type II inteferon signaling.Transforming potential of the adenovirus type 5 E4orf3 protein.Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication.Biphasic recruitment of transcriptional repressors to the murine cytomegalovirus major immediate-early promoter during the course of infection in vivoDNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretionDisruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PMLDefective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant.The disruption of ND10 during herpes simplex virus infection correlates with the Vmw110- and proteasome-dependent loss of several PML isoformsElimination of ie1 significantly attenuates murine cytomegalovirus virulence but does not alter replicative capacity in cell cultureThe human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells.Role of human cytomegalovirus immediate-early proteins in cell growth control.The Epstein-Barr virus BZLF1 protein interacts physically and functionally with the histone acetylase CREB-binding protein.Perturbation of cell cycle progression and cellular gene expression as a function of herpes simplex virus ICP0.The human cytomegalovirus IE2 and UL112-113 proteins accumulate in viral DNA replication compartments that initiate from the periphery of promyelocytic leukemia protein-associated nuclear bodies (PODs or ND10)The major immediate-early gene ie3 of mouse cytomegalovirus is essential for viral growth.Efficient activation of viral genomes by levels of herpes simplex virus ICP0 insufficient to affect cellular gene expression or cell survival.Evaluation of interactions of human cytomegalovirus immediate-early IE2 regulatory protein with small ubiquitin-like modifiers and their conjugation enzyme Ubc9Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γAn E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus.Regulation of the subcellular distribution of key cellular RNA-processing factors during permissive human cytomegalovirus infection
P2860
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P2860
The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
The major immediate-early prot ...... in infected permissive cells.
@ast
The major immediate-early prot ...... in infected permissive cells.
@en
type
label
The major immediate-early prot ...... in infected permissive cells.
@ast
The major immediate-early prot ...... in infected permissive cells.
@en
prefLabel
The major immediate-early prot ...... in infected permissive cells.
@ast
The major immediate-early prot ...... in infected permissive cells.
@en
P2860
P1433
P1476
The major immediate-early prot ...... s in infected permissive cells
@en
P2093
P2860
P304
P407
P577
1997-06-01T00:00:00Z