Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia - Wikidata - wikimedia - TriplyDB

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

http://www.wikidata.org/entity/Q35901705

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The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases Recent advances in diagnosis, molecular pathology and therapy of chronic myelomonocytic leukaemia Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders Bone marrow morphology and disease progression in congenital thrombocytopenia: a detailed clinicopathologic and genetic study of eight cases.CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases.Global Cell Proteome Profiling, Phospho-signaling and Quantitative Proteomics for Identification of New Biomarkers in Acute Myeloid Leukemia Patients Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions.Cbl and human myeloid neoplasms: the Cbl oncogene comes of age.Antagonizing c-Cbl enhances EGFR-dependent corneal epithelial homeostasis Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells.Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain.Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia.Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.The role of the c-Met pathway in lung cancer and the potential for targeted therapy.Molecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment.Management of Two Juvenile Myelomonocytic Leukemia Patients According to Clinical and Genetic Features.Deleterious c-Cbl Exon Skipping Contributes to Human Glioma.Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia.c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia Genetic predispositions to childhood leukemia.The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.JAK2 V617F and beyond: role of genetics and aberrant signaling in the pathogenesis of myeloproliferative neoplasms.Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Genetic and epigenetic alterations of myeloproliferative disorders.Role of the ubiquitin proteasome system in hematologic malignancies.

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Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

http://www.wikidata.org/entity/Q35901705

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

@zh-cn

name

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

@ast

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

@en

type

label

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

@ast

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

@en

prefLabel

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

@ast

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

@en

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BLOOD-2006-12-061176

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Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

@en

P2093

Danilo Perrotti

http://www.w3.org/2001/XMLSchema#string

Jianhua Yu

http://www.w3.org/2001/XMLSchema#string

Jing Wen

http://www.w3.org/2001/XMLSchema#string

Kristy J Arnoczky

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Lisheng Wang

http://www.w3.org/2001/XMLSchema#string

Michael A Caligiuri

http://www.w3.org/2001/XMLSchema#string

Min Wei

http://www.w3.org/2001/XMLSchema#string

Roger Briesewitz

http://www.w3.org/2001/XMLSchema#string

Susan P Whitman

http://www.w3.org/2001/XMLSchema#string

Trent B Marburger

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P2860

Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

The Cbl family of signal transduction molecules

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl.

RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.

Cbl: many adaptations to regulate protein tyrosine kinases.

Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.

Alterations of pre-mRNA splicing in cancer.

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1022-1024

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scholarly article

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10.1182/BLOOD-2006-12-061176

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3

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Clara D. Bloomfield

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2007-05-02T00:00:00Z

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17475912

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1924768

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