Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.
about
Threshold-controlled ubiquitination of the EGFR directs receptor fateA novel role of Sprouty 2 in regulating cellular apoptosisThe Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitiStructural basis for autoinhibition and phosphorylation-dependent activation of c-CblRING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitinationProtein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligasesRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisRaf activation is regulated by tyrosine 510 phosphorylation in DrosophilaAutoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-bEssentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3Conformational changes in protein loops and helices induced by post-translational phosphorylation.Cbl negatively regulates JNK activation and cell deathCasitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformationTemporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiationProtein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis.The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.Mechanism and functional significance of Itk autophosphorylation.FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion.Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation.Regulation of ROMK (Kir1.1) channels: new mechanisms and aspects.Cbl and human myeloid neoplasms: the Cbl oncogene comes of age.ROMK1 channel activity is regulated by monoubiquitinationE3 ubiquitin ligase Cbl-b in innate and adaptive immunity.Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype.Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia.Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5.Proteomic snapshot of the EGF-induced ubiquitin networkMacromolecular juggling by ubiquitylation enzymes.The E3 ligase c-Cbl regulates dendritic cell activationMolecular pathways: cbl proteins in tumorigenesis and antitumor immunity-opportunities for cancer treatment.Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemiaEGF receptor ubiquitination is not necessary for its internalization.c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.The importance of serine 776 in Ataxin-1 partner selection: a FRET analysis.Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnoverαE-catenin inhibits a Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway.Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis.
P2860
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P2860
Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Regulation of ubiquitin protei ...... to glutamate point mutations.
@ast
Regulation of ubiquitin protei ...... to glutamate point mutations.
@en
Regulation of ubiquitin protei ...... to glutamate point mutations.
@nl
type
label
Regulation of ubiquitin protei ...... to glutamate point mutations.
@ast
Regulation of ubiquitin protei ...... to glutamate point mutations.
@en
Regulation of ubiquitin protei ...... to glutamate point mutations.
@nl
prefLabel
Regulation of ubiquitin protei ...... to glutamate point mutations.
@ast
Regulation of ubiquitin protei ...... to glutamate point mutations.
@en
Regulation of ubiquitin protei ...... to glutamate point mutations.
@nl
P2860
P356
P1476
Regulation of ubiquitin protei ...... to glutamate point mutations.
@en
P2093
C Kenneth Kassenbrock
Steven M Anderson
P2860
P304
28017-28027
P356
10.1074/JBC.M404114200
P407
P577
2004-04-26T00:00:00Z