about
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitorThe Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineageDickkopf-1 regulates bone formation in young growing rodents and upon traumatic injuryA role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentitionGeneration and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivoLrp4 modulates extracellular integration of cell signaling pathways in development.Modulation of Wnt signaling influences fracture repairAssociation of LRP5 genotypes with osteoporosis in Tunisian post-menopausal womenMeta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass.Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation.Wnts' fashion statement: from body stature to dysplasia.Basic and clinical aspects of osteoporosis in inflammatory bowel disease.HIV-1 protein induced modulation of primary human osteoblast differentiation and function via a Wnt/β-catenin-dependent mechanism.Rare LRP6 variants identified in spina bifida patients.Resolving the Two "Bony" Faces of PPAR-gamma.The role of Lrp5/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE-/- /Lrp5-/- mice.Molecular genetic studies of gene identification for osteoporosis: a 2004 update.Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in menOsteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies.Sclerostin antibody increases bone volume and enhances implant fixation in a rat model.Wnt signalling pathway: a new target for the treatment of osteoporosis.Turning down the system: counter-regulatory mechanisms in bone and adaptive immunity.Glucagon-like peptide-1(GLP-1) receptor agonists: potential to reduce fracture risk in diabetic patients?Interactions between microenvironment and cancer cells in two animal models of bone metastasisThe evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapiesOsteogenic regulation of vascular calcification.Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signalingChanges in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levelsDiseases of Wnt signaling.Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralizationWnt signaling control of bone cell apoptosis.A bivariate whole genome linkage study identified genomic regions influencing both BMD and bone structure.The first propeller domain of LRP6 regulates sensitivity to DKK1.How genomics has informed our understanding of the pathogenesis of osteoporosis.Pax6 expressed in osteocytes inhibits canonical Wnt signaling.LRP5 gene polymorphism and cortical bone.Glucocorticoid excess in mice results in early activation of osteoclastogenesis and adipogenesis and prolonged suppression of osteogenesis: a longitudinal study of gene expression in bone tissue from glucocorticoid-treated mice.The role of Lrp5/6 in cardiac valve disease: LDL-density-pressure theory.Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signalingSclerostin: therapeutic horizons based upon its actions.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
LRP5 and Wnt signaling: a union made for bone.
@ast
LRP5 and Wnt signaling: a union made for bone.
@en
type
label
LRP5 and Wnt signaling: a union made for bone.
@ast
LRP5 and Wnt signaling: a union made for bone.
@en
prefLabel
LRP5 and Wnt signaling: a union made for bone.
@ast
LRP5 and Wnt signaling: a union made for bone.
@en
P2093
P2860
P356
P1476
LRP5 and Wnt signaling: a union made for bone.
@en
P2093
Kimberley Harnish
Mark L Johnson
Roel Nusse
P2860
P304
P356
10.1359/JBMR.040816
P50
P577
2004-08-23T00:00:00Z